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Peters M, de Leeuw AAC, Nomden CN, et al. Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis. Radiother Oncol. 2021;163:150-158doi: 10.1016/j.radonc.2021.08.020.
Peters, M., de Leeuw, A. A. C., Nomden, C. N., Tanderup, K., Kirchheiner, K., Lindegaard, J. C., Kirisits, C., Haie-Meder, C., Sturdza, A., Fokdal, L., Mahantshetty, U., Hoskin, P., Segedin, B., Bruheim, K., Rai, B., Huang, F., Cooper, R., van der Steen-Banasik, E., van Limbergen, E., Pieters, B. R., Tan, L. T., van Rossum, P. S. N., Nesvacil, N., Nout, R., Schmid, M. P., Pötter, R., Jürgenliemk-Schulz, I. M. (2021). Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 163150-158. https://doi.org/10.1016/j.radonc.2021.08.020
Peters, Max, et al. "Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology vol. 163 (2021): 150-158. doi: https://doi.org/10.1016/j.radonc.2021.08.020
Peters M, de Leeuw AAC, Nomden CN, Tanderup K, Kirchheiner K, Lindegaard JC, Kirisits C, Haie-Meder C, Sturdza A, Fokdal L, Mahantshetty U, Hoskin P, Segedin B, Bruheim K, Rai B, Huang F, Cooper R, van der Steen-Banasik E, van Limbergen E, Pieters BR, Tan LT, van Rossum PSN, Nesvacil N, Nout R, Schmid MP, Pötter R, Jürgenliemk-Schulz IM. Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis. Radiother Oncol. 2021 Oct;163:150-158. doi: 10.1016/j.radonc.2021.08.020. Epub 2021 Sep 02. PMID: 34480958.
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Radiother Oncol. 2021 Oct;163:150-158. doi: 10.1016/j.radonc.2021.08.020. Epub 2021 Sep 02.

Risk factors for nodal failure after radiochemotherapy and image guided brachytherapy in locally advanced cervical cancer: An EMBRACE analysis.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Max Peters, Astrid A C de Leeuw, Christel N Nomden, Kari Tanderup, Kathrin Kirchheiner, Jacob C Lindegaard, Christian Kirisits, Christine Haie-Meder, Alina Sturdza, Lars Fokdal, Umesh Mahantshetty, Peter Hoskin, Barbara Segedin, Kjersti Bruheim, Bhavana Rai, Fleur Huang, Rachel Cooper, Elzbieta van der Steen-Banasik, Erik van Limbergen, Bradley R Pieters, Li Tee Tan, Peter S N van Rossum, Nicole Nesvacil, Remi Nout, Maximilian P Schmid, Richard Pötter, Ina M Jürgenliemk-Schulz,

Affiliations

  1. University Medical Center Utrecht, Department of Radiation Oncology, Utrecht, The Netherlands. Electronic address: [email protected].
  2. University Medical Center Utrecht, Department of Radiation Oncology, Utrecht, The Netherlands.
  3. Aarhus University Hospital, Department of Oncology, Aarhus, Denmark.
  4. Department of Radiation Oncology, Comprehensive Cancer Center, Medical University of Vienna, General Hospital of Vienna, Austria.
  5. Gustave-Roussy, Department of Radiotherapy, Villejuif, France.
  6. Tata Memorial Hospital, Department of Radiation Oncology, Mumbai, India.
  7. Mount Vernon Cancer Centre, Northwood, United Kingdom.
  8. Institute of Oncology Ljubljana, Department of Radiotherapy, Ljubljana, Slovenia.
  9. The Norwegian Radium Hospital-Oslo University Hospital, Department of Oncology, Oslo, Norway.
  10. Postgraduate Institute of Medical Education and Research, Department of Radiotherapy and Oncology, Chandigarh, India.
  11. Department of Oncology, Cross Cancer Institute and University of Alberta, Edmonton, Canada.
  12. St James's University Hospital, Leeds Cancer Centre, Leeds, United Kingdom.
  13. Radiotherapiegroep Arnhem, Department of Radiotherapy, Arnhem, the Netherlands.
  14. UZ Leuven, Department of Radiation Oncology, Leuven, Belgium.
  15. Department of Radiation Oncology, Amsterdam University Medical Centers, University of Amsterdam, the Netherlands.
  16. Department of Oncology, Addenbrooke's Hospital, Cambridge University Hospitals, United Kingdom.
  17. Leiden University Medical Center, Department of Radiation Oncology, Leiden, the Netherlands.

PMID: 34480958 DOI: 10.1016/j.radonc.2021.08.020

Abstract

OBJECTIVE: To assess risk factors for nodal failure (NF) after definitive (chemo)radiotherapy and image-guided brachytherapy for locally advanced cervical cancer (LACC) for patients treated in the EMBRACE I study.

MATERIALS AND METHODS: Data for pelvic NF and para-aortic (PAO) NF (NF

RESULTS: 1338 patients with 152 NF and 104 NF

CONCLUSION: In this patient cohort, nodal disease and tumour width at diagnosis, as well as local failure, are risk factors for NF after definitive treatment. Having either 'any PAO nodes' (with or without pelvic nodes) or 'any CI nodes' (without PAO nodes) are stronger risk factors than involvement of nodes in the small pelvis alone. Elective PAO-irradiation was associated with significantly less NF

Crown Copyright © 2021. Published by Elsevier B.V. All rights reserved.

Keywords: (Para-aortic) nodal failure; EMBRACE; Risk factors

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