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Gheller BJ, Blum JE, Fong EHH, et al. A defined N6-methyladenosine (m. Cell Death Discov. 2020;6(1):95doi: 10.1038/s41420-020-00328-5.
Gheller, B. J., Blum, J. E., Fong, E. H. H., Malysheva, O. V., Cosgrove, B. D., & Thalacker-Mercer, A. E. (2020). A defined N6-methyladenosine (m. Cell death discovery, 6(1), 95. https://doi.org/10.1038/s41420-020-00328-5
Gheller, Brandon J, et al. "A defined N6-methyladenosine (m." Cell death discovery vol. 6,1 (2020): 95. doi: https://doi.org/10.1038/s41420-020-00328-5
Gheller BJ, Blum JE, Fong EHH, Malysheva OV, Cosgrove BD, Thalacker-Mercer AE. A defined N6-methyladenosine (m. Cell Death Discov. 2020 Sep 29;6(1):95. doi: 10.1038/s41420-020-00328-5. eCollection 2020. PMID: 33083017; PMCID: PMC7524727.
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Cell Death Discov. 2020 Sep 29;6(1):95. doi: 10.1038/s41420-020-00328-5. eCollection 2020.

A defined N6-methyladenosine (m.

Cell death discovery

Brandon J Gheller, Jamie E Blum, Ern Hwei Hannah Fong, Olga V Malysheva, Benjamin D Cosgrove, Anna E Thalacker-Mercer

Affiliations

  1. Division of Nutritional Sciences, Cornell University, Ithaca, NY USA.
  2. Meinig School of Biomedical Engineering, Cornell University, Ithaca, NY USA.
  3. Center for Exercise Medicine, University of Alabama at Birmingham, Birmingham, AL USA.
  4. Department of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL USA.

PMID: 33083017 PMCID: PMC7524727 DOI: 10.1038/s41420-020-00328-5

Abstract

Muscle-specific adult stem cells (MuSCs) are required for skeletal muscle regeneration. To ensure efficient skeletal muscle regeneration after injury, MuSCs must undergo state transitions as they are activated from quiescence, give rise to a population of proliferating myoblasts, and continue either to terminal differentiation, to repair or replace damaged myofibers, or self-renewal to repopulate the quiescent population. Changes in MuSC/myoblast state are accompanied by dramatic shifts in their transcriptional profile. Previous reports in other adult stem cell systems have identified alterations in the most abundant internal mRNA modification, N6-methyladenosine (m

© The Author(s) 2020.

Keywords: Muscle stem cells; Stem-cell differentiation; Transcriptomics

Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

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