Display options
Cite
Khoshbin K, Khanna L, Maselli D, et al. Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults. Gastroenterology. 2021;161(2):463-475.e13doi: 10.1053/j.gastro.2021.04.020.
Khoshbin, K., Khanna, L., Maselli, D., Atieh, J., Breen-Lyles, M., Arndt, K., Rhoten, D., Dyer, R. B., Singh, R. J., Nayar, S., Bjerkness, S., Harmsen, W. S., Busciglio, I., & Camilleri, M. (2021). Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults. Gastroenterology, 161(2), 463-475.e13. https://doi.org/10.1053/j.gastro.2021.04.020
Khoshbin, Katayoun, et al. "Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults." Gastroenterology vol. 161,2 (2021): 463-475.e13. doi: https://doi.org/10.1053/j.gastro.2021.04.020
Khoshbin K, Khanna L, Maselli D, Atieh J, Breen-Lyles M, Arndt K, Rhoten D, Dyer RB, Singh RJ, Nayar S, Bjerkness S, Harmsen WS, Busciglio I, Camilleri M. Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults. Gastroenterology. 2021 Aug;161(2):463-475.e13. doi: 10.1053/j.gastro.2021.04.020. Epub 2021 Apr 16. PMID: 33865841; PMCID: PMC8328885.
Copy Download .nbib Format: NLM
Share it on

Gastroenterology. 2021 Aug;161(2):463-475.e13. doi: 10.1053/j.gastro.2021.04.020. Epub 2021 Apr 16.

Development and Validation of Test for "Leaky Gut" Small Intestinal and Colonic Permeability Using Sugars in Healthy Adults.

Gastroenterology

Katayoun Khoshbin, Lehar Khanna, Daniel Maselli, Jessica Atieh, Margaret Breen-Lyles, Kayla Arndt, Deborah Rhoten, Roy B Dyer, Ravinder J Singh, Sunita Nayar, Sandra Bjerkness, William S Harmsen, Irene Busciglio, Michael Camilleri

Affiliations

  1. Clinical Enteric NeuroscienceTranslational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.
  2. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.
  3. Clinical Research and Trials Unit, Mayo Clinic, Rochester, Minnesota.
  4. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota.
  5. Clinical Enteric NeuroscienceTranslational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address: [email protected].

PMID: 33865841 PMCID: PMC8328885 DOI: 10.1053/j.gastro.2021.04.020

Abstract

BACKGROUND: Oral monosaccharides and disaccharides are used to measure in vivo human gut permeability through urinary excretion.

AIMS: The aims were as follows: (1) to obtain normative data on small intestinal and colonic permeability; (2) to assess variance on standard 16 g fiber diet performed twice; (3) to determine whether dietary fiber influences gut permeability measurements; and (4) to present pilot data using 2 selected probes in patients with diarrhea-predominant irritable bowel syndrome (IBS-D).

METHODS: Sixty healthy female and male adults, age 18-70 years, participated in 3 randomized studies (2 studies on 16.25 g and 1 study on 32.5 g fiber) in otherwise standardized diets. At each test, the following sugars were ingested:

RESULTS: Baseline sugars (>3-fold above lower limits of quantitation) were identified in the 3 studies:

CONCLUSIONS: Baseline

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Keywords: Barrier; Lactulose; Mannitol; Sucralose

References

  1. Med Sci Sports Exerc. 2014 Nov;46(11):2039-46 - PubMed
  2. Neurogastroenterol Motil. 2009 Jul;21(7):734-e43 - PubMed
  3. BMC Gastroenterol. 2014 Nov 18;14:189 - PubMed
  4. Sports Med. 2017 Jul;47(7):1389-1403 - PubMed
  5. Clin Biochem. 2008 Jul;41(10-11):887-92 - PubMed
  6. J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):269-75 - PubMed
  7. Acta Psychiatr Scand. 1983 Jun;67(6):361-70 - PubMed
  8. J Nutr. 2003 Feb;133(2):609S-23S - PubMed
  9. Gastroenterology. 2006 Apr;130(5):1480-91 - PubMed
  10. Neurogastroenterol Motil. 2010 Jan;22(1):e15-26 - PubMed
  11. Gastroenterology. 2010 Jan;138(1):65-72.e1-2 - PubMed
  12. Gastroenterology. 2018 Feb;154(3):500-514 - PubMed
  13. Gastroenterology. 1998 Jan;114(1):83-92 - PubMed
  14. Am J Gastroenterol. 2014 Oct;109(10):1621-30 - PubMed
  15. Clin Biochem. 2018 Feb;52:106-111 - PubMed
  16. Gut. 2019 Aug;68(8):1516-1526 - PubMed
  17. Neurogastroenterol Motil. 2016 Jul;28(7):1114-9 - PubMed
  18. Am J Physiol Gastrointest Liver Physiol. 2019 Jul 1;317(1):G17-G39 - PubMed
  19. BMJ Glob Health. 2016 Jul 4;1(1):e000066 - PubMed
  20. Clin Sci (Lond). 2015 Oct;129(7):515-27 - PubMed
  21. Mayo Clin Proc. 1990 Nov;65(11):1456-79 - PubMed
  22. J Gen Microbiol. 1982 Feb;128(2):319-25 - PubMed
  23. Nat Rev Gastroenterol Hepatol. 2017 Jan;14(1):9-21 - PubMed
  24. Curr Opin Gastroenterol. 2016 Mar;32(2):74-9 - PubMed
  25. Nat Rev Gastroenterol Hepatol. 2012 Sep 04;9(10):577-89 - PubMed
  26. Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G919-28 - PubMed
  27. Eur J Appl Physiol. 2017 Dec;117(12):2519-2526 - PubMed

Publication Types

Grant support