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Olesen CS, Koch T, Uldbjerg CS, et al. Cardiovascular mortality after bilateral oophorectomy: a prospective cohort study. Menopause. 2021;29(1):28-34doi: 10.1097/GME.0000000000001873.
Olesen, C. S., Koch, T., Uldbjerg, C. S., Gregersen, L. S., Christensen, J., Dehlendorff, C., Priskorn, L., Wilson, L. F., Lim, Y. H., Jørgensen, J. T., Andersen, Z. J., Juul, A., Abildgaard, J., Hickey, M., & Bräuner, E. V. (2021). Cardiovascular mortality after bilateral oophorectomy: a prospective cohort study. Menopause (New York, N.Y.), 29(1), 28-34. https://doi.org/10.1097/GME.0000000000001873
Olesen, Cathrine S, et al. "Cardiovascular mortality after bilateral oophorectomy: a prospective cohort study." Menopause (New York, N.Y.) vol. 29,1 (2021): 28-34. doi: https://doi.org/10.1097/GME.0000000000001873
Olesen CS, Koch T, Uldbjerg CS, Gregersen LS, Christensen J, Dehlendorff C, Priskorn L, Wilson LF, Lim YH, Jørgensen JT, Andersen ZJ, Juul A, Abildgaard J, Hickey M, Bräuner EV. Cardiovascular mortality after bilateral oophorectomy: a prospective cohort study. Menopause. 2021 Nov 01;29(1):28-34. doi: 10.1097/GME.0000000000001873. PMID: 34726195.
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Menopause. 2021 Nov 01;29(1):28-34. doi: 10.1097/GME.0000000000001873.

Cardiovascular mortality after bilateral oophorectomy: a prospective cohort study.

Menopause (New York, N.Y.)

Cathrine S Olesen, Trine Koch, Cecilie S Uldbjerg, Laura S Gregersen, Jane Christensen, Christian Dehlendorff, Lærke Priskorn, Louise F Wilson, Youn-Hee Lim, Jeanette T Jørgensen, Zorana J Andersen, Anders Juul, Julie Abildgaard, Martha Hickey, Elvira V Bräuner

Affiliations

  1. Department of Growth and Reproduction, Copenhagen University Hospital - Rigshospitalet, Denmark.
  2. The International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  3. Statistics and Data Analysis, Danish Cancer Society, Copenhagen, Denmark.
  4. The University of Queensland, NHMRC Centre for Research Excellence on Women and Non-communicable Diseases (CREWaND), School of Public Health, Herston Road, Herston, Queensland, Australia.
  5. Section of Environmental Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.
  6. Seoul National University Medical Research Center, Seoul, Republic of Korea.
  7. Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  8. Centre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
  9. Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia.

PMID: 34726195 DOI: 10.1097/GME.0000000000001873

Abstract

OBJECTIVES: Bilateral oophorectomy permanently reduces endogenous estrogen exposure and may increase cardiovascular mortality in women. This study aimed to investigate the association between bilateral oophorectomy and cardiovascular mortality and whether this association was conditional on hysterectomy or on the use of hormone therapy at the time of study entry.

METHODS: A prospective cohort study of 25,338 female nurses aged ≥ 45 years within the Danish Nurse Cohort. Nurses were enrolled in 1993 or 1999 and followed until death, emigration, or end of follow-up on December 31, 2018, whichever came first. Exposure was bilateral oophorectomy. Outcome was cardiovascular mortality. Associations were estimated using Poisson regression models with log person-years as the offset.

RESULTS: A total of 2,040 (8.1%) participants underwent bilateral oophorectomy. During a mean follow-up of 21.2 (SD: 5.6) years, 772 (3.0%) nurses died from cardiovascular disease. In adjusted analyses, a 31% higher rate of cardiovascular mortality was observed after bilateral oophorectomy (aMRR 1.31; 95% CI, 0.88-1.96) compared with women who retained their ovaries. No evidence of effect modification by use of hormone therapy at baseline or by hysterectomy on the association between bilateral oophorectomy and cardiovascular mortality was observed.

CONCLUSION: Bilateral oophorectomy may be associated with cardiovascular mortality in women, but the estimate was not statistically significant. Additionally, we were unable to make firm conclusions regarding the possible modifying role of hormone therapy and hysterectomy on this potential association. Additional studies are needed to replicate this work.

Copyright © 2021 by The North American Menopause Society.

Conflict of interest statement

Financial disclosure/conflicts of interest: None reported.

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