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Rukoyatkina N, Shpakova V, Bogoutdinova A, et al. Curcumin by activation of adenosine A. Biochem Biophys Res Commun. 2021;586:20-26doi: 10.1016/j.bbrc.2021.11.006.
Rukoyatkina, N., Shpakova, V., Bogoutdinova, A., Kharazova, A., Mindukshev, I., & Gambaryan, S. (2022). Curcumin by activation of adenosine A. Biochemical and biophysical research communications, 58620-26. https://doi.org/10.1016/j.bbrc.2021.11.006
Rukoyatkina, Natalia, et al. "Curcumin by activation of adenosine A." Biochemical and biophysical research communications vol. 586 (2022): 20-26. doi: https://doi.org/10.1016/j.bbrc.2021.11.006
Rukoyatkina N, Shpakova V, Bogoutdinova A, Kharazova A, Mindukshev I, Gambaryan S. Curcumin by activation of adenosine A. Biochem Biophys Res Commun. 2022 Jan 01;586:20-26. doi: 10.1016/j.bbrc.2021.11.006. Epub 2021 Nov 04. PMID: 34823218.
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Biochem Biophys Res Commun. 2022 Jan 01;586:20-26. doi: 10.1016/j.bbrc.2021.11.006. Epub 2021 Nov 04.

Curcumin by activation of adenosine A.

Biochemical and biophysical research communications

Natalia Rukoyatkina, Valentina Shpakova, Alina Bogoutdinova, Alexandra Kharazova, Igor Mindukshev, Stepan Gambaryan

Affiliations

  1. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Thorez Prospect 44, Saint Petersburg, 194223, Russia. Electronic address: [email protected].
  2. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Thorez Prospect 44, Saint Petersburg, 194223, Russia. Electronic address: [email protected].
  3. Saint Petersburg State Chemical Pharmaceutical University, Professora Popova Street 14, Saint Petersburg, 197376, Russia. Electronic address: [email protected].
  4. Saint Petersburg State University, 7/9 Universitetskaya Emb., Saint Petersburg, 199034, Russia. Electronic address: [email protected].
  5. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Thorez Prospect 44, Saint Petersburg, 194223, Russia. Electronic address: [email protected].
  6. Sechenov Institute of Evolutionary Physiology and Biochemistry of the Russian Academy of Sciences, Thorez Prospect 44, Saint Petersburg, 194223, Russia. Electronic address: [email protected].

PMID: 34823218 DOI: 10.1016/j.bbrc.2021.11.006

Abstract

Curcumin is a natural polyphenol derived from the turmeric plant (Curcuma longa) which exhibits numerous beneficial effects on different cell types. Inhibition of platelet activation by curcumin is well known, however molecular mechanisms of its action on platelets are not fully defined. In this study, we used laser diffraction method for analysis of platelet aggregation and Western blot for analysis of intracellular signaling mechanisms of curcumin effects on platelets. We identified two new molecular mechanisms involved in the inhibitory effects of curcumin on platelet activation. Firstly, curcumin by activation of adenosine A

Copyright © 2021. Published by Elsevier Inc.

Keywords: A(2A) receptor; Adenosine; Curcumin; Platelets; Protein kinase A

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