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Bowes CL, Naranbhai V, St Denis KJ, et al. Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy. Radiother Oncol. 2021;166:88-91doi: 10.1016/j.radonc.2021.11.012.
Bowes, C. L., Naranbhai, V., St Denis, K. J., Lam, E. C., Bertaux, B., Keane, F. K., Khandekar, M. J., Balazs, A. B., Iafrate, J. A., Gainor, J. F., & Willers, H. (2021). Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 16688-91. https://doi.org/10.1016/j.radonc.2021.11.012
Bowes, Cynthia L, et al. "Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology vol. 166 (2021): 88-91. doi: https://doi.org/10.1016/j.radonc.2021.11.012
Bowes CL, Naranbhai V, St Denis KJ, Lam EC, Bertaux B, Keane FK, Khandekar MJ, Balazs AB, Iafrate JA, Gainor JF, Willers H. Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy. Radiother Oncol. 2021 Nov 25;166:88-91. doi: 10.1016/j.radonc.2021.11.012. Epub 2021 Nov 25. PMID: 34838892; PMCID: PMC8613981.
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Radiother Oncol. 2021 Nov 25;166:88-91. doi: 10.1016/j.radonc.2021.11.012. Epub 2021 Nov 25.

Heterogeneous immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Cynthia L Bowes, Vivek Naranbhai, Kerri J St Denis, Evan C Lam, Brittany Bertaux, Florence K Keane, Melin J Khandekar, Alejandro B Balazs, John A Iafrate, Justin F Gainor, Henning Willers

Affiliations

  1. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA.
  2. Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
  3. Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, USA.
  4. Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.
  5. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. Electronic address: [email protected].

PMID: 34838892 PMCID: PMC8613981 DOI: 10.1016/j.radonc.2021.11.012

Abstract

The immunogenicity of SARS-CoV-2 vaccines in cancer patients receiving radiotherapy is unknown. This prospective cohort study demonstrates that anti-SARS-CoV-2 spike antibody and neutralization titers are reduced in a subset of thoracic radiotherapy patients, possibly due to immunosuppressive conditions. Antibody testing may be useful to identify candidates for additional vaccine doses.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: COVID-19; Immunogenicity; Lung cancer; Radiotherapy; SARS-CoV-2; mRNA vaccine

Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Gainor has served as a comp

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