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Olawale OO, Adekanmbi AF, Sonuga AA, et al. Assessment of Renal Function Status in Steady-State Sickle Cell Anaemic Children Using Urine Human Neutrophil Gelatinase-Associated Lipocalin and Albumin:Creatinine Ratio. Med Princ Pract. 2021;30(6):557-562doi: 10.1159/000518458.
Olawale, O. O., Adekanmbi, A. F., Sonuga, A. A., Sonuga, O. O., Akodu, S. O., & Ogundeyi, M. M. (2021). Assessment of Renal Function Status in Steady-State Sickle Cell Anaemic Children Using Urine Human Neutrophil Gelatinase-Associated Lipocalin and Albumin:Creatinine Ratio. Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 30(6), 557-562. https://doi.org/10.1159/000518458
Olawale, Olatubosun Oladipupo, et al. "Assessment of Renal Function Status in Steady-State Sickle Cell Anaemic Children Using Urine Human Neutrophil Gelatinase-Associated Lipocalin and Albumin:Creatinine Ratio." Medical principles and practice : international journal of the Kuwait University, Health Science Centre vol. 30,6 (2021): 557-562. doi: https://doi.org/10.1159/000518458
Olawale OO, Adekanmbi AF, Sonuga AA, Sonuga OO, Akodu SO, Ogundeyi MM. Assessment of Renal Function Status in Steady-State Sickle Cell Anaemic Children Using Urine Human Neutrophil Gelatinase-Associated Lipocalin and Albumin:Creatinine Ratio. Med Princ Pract. 2021;30(6):557-562. doi: 10.1159/000518458. Epub 2021 Jul 14. PMID: 34348300.
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Med Princ Pract. 2021;30(6):557-562. doi: 10.1159/000518458. Epub 2021 Jul 14.

Assessment of Renal Function Status in Steady-State Sickle Cell Anaemic Children Using Urine Human Neutrophil Gelatinase-Associated Lipocalin and Albumin:Creatinine Ratio.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre

Olatubosun Oladipupo Olawale, Abiodun Folasade Adekanmbi, Ayobola Abimbola Sonuga, Oyebola Oluwagbemiga Sonuga, Samuel Olufemi Akodu, Morufat Mojisola Ogundeyi

Affiliations

  1. Department of Chemical Pathology and Immunology, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria.
  2. Department of Paediatrics, Olabisi Onabanjo University Teaching Hospital, Sagamu, Nigeria.
  3. Department of Biochemistry, Lead City University, Ibadan, Nigeria.
  4. Department of Chemical Pathology, University College Hospital, Ibadan, Nigeria.
  5. Department of Paediatrics, Federal Medical Center, Abeokuta, Nigeria.

PMID: 34348300 DOI: 10.1159/000518458

Abstract

INTRODUCTION: Sickle cell anaemia is characterized by defective haemoglobin synthesis and is associated with both endocrine and metabolic alterations. The effects of this clinical condition on kidney function are multifactorial and often begin early in childhood. This study aims to assess renal function in children with sickle cell anaemia using urine albumin:creatinine ratio (ACR) and urine human neutrophil gelatinase-associated lipocalin (NGAL).

METHODS: This case-control study was conducted on 200 children aged 5-15 years in 2 tertiary hospitals in South West Nigeria: 150 were of haemoglobin S genotype and 50 were of haemoglobin A genotype. Serum urea, creatinine, urine albumin, and NGAL were assayed by known standard methods. eGFR, urine ACR, and urine NGAL/creatinine ratio (urine NCR) were calculated.

RESULTS: The weight, height, BMI, systolic blood pressure, plasma urea, plasma creatinine, and spot urine creatinine of the HbS genotype children were significantly lower compared to that of the HbA genotype children. The eGFR, spot urine albumin, and urine ACR were significantly higher in the HbS group compared to the HbA group. There was no significant difference in the spot urine NGAL and urine NCR between the 2 groups, though both were higher in the HbS group compared to the HbA group.

CONCLUSIONS: Kidney injury probably starts early in childhood in sickle cell individuals as indicated by the higher urine ACR detected in them. We infer that urine NGAL and uNCR are not sensitive markers of kidney disease especially in young sickle cell individuals possibly because of the hyperfiltration present at this age.

© 2021 The Author(s) Published by S. Karger AG, Basel.

Keywords: Human neutrophil gelatinase-associated lipocalin; Renal function; Sickle cell anaemia; Urine albumin creatinine ratio

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