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Pal G, Ramirez V, Engen PA, et al. Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease. NPJ Parkinsons Dis. 2021;7(1):111doi: 10.1038/s41531-021-00254-y.
Pal, G., Ramirez, V., Engen, P. A., Naqib, A., Forsyth, C. B., Green, S. J., Mahdavinia, M., Batra, P. S., Tajudeen, B. A., & Keshavarzian, A. (2021). Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease. NPJ Parkinson's disease, 7(1), 111. https://doi.org/10.1038/s41531-021-00254-y
Pal, Gian, et al. "Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease." NPJ Parkinson's disease vol. 7,1 (2021): 111. doi: https://doi.org/10.1038/s41531-021-00254-y
Pal G, Ramirez V, Engen PA, Naqib A, Forsyth CB, Green SJ, Mahdavinia M, Batra PS, Tajudeen BA, Keshavarzian A. Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease. NPJ Parkinsons Dis. 2021 Dec 08;7(1):111. doi: 10.1038/s41531-021-00254-y. PMID: 34880258; PMCID: PMC8655044.
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NPJ Parkinsons Dis. 2021 Dec 08;7(1):111. doi: 10.1038/s41531-021-00254-y.

Deep nasal sinus cavity microbiota dysbiosis in Parkinson's disease.

NPJ Parkinson's disease

Gian Pal, Vivian Ramirez, Phillip A Engen, Ankur Naqib, Christopher B Forsyth, Stefan J Green, Mahboobeh Mahdavinia, Pete S Batra, Bobby A Tajudeen, Ali Keshavarzian

Affiliations

  1. Department of Neurology, Rush University Medical Center, Chicago, IL, USA.
  2. Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, USA.
  3. Genomics and Microbiome Core Facility, Rush University Medical Center, Chicago, IL, USA.
  4. Department of Internal Medicine, Division of Infectious Diseases, Rush University Medical Center, Chicago, IL, USA.
  5. Department of Internal Medicine, Allergy/Immunology Division, Rush University Medical Center, Chicago, IL, USA.
  6. Department of Otorhinolaryngology-Head and Neck Surgery, Rush University Medical Center, Chicago, IL, USA.
  7. Rush Medical College, Rush Center for Integrated Microbiome and Chronobiology Research, Rush University Medical Center, Chicago, IL, USA. [email protected].
  8. Department of Medicine & Physiology, Rush University Medical Center, Chicago, IL, USA. [email protected].
  9. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands. [email protected].

PMID: 34880258 PMCID: PMC8655044 DOI: 10.1038/s41531-021-00254-y

Abstract

Olfactory dysfunction is a pre-motor symptom of Parkinson's disease (PD) that appears years prior to diagnosis and can affect quality of life in PD. Changes in microbiota community in deep nasal cavity near the olfactory bulb may trigger the olfactory bulb-mediated neuroinflammatory cascade and eventual dopamine loss in PD. To determine if the deep nasal cavity microbiota of PD is significantly altered in comparison to healthy controls, we characterized the microbiota of the deep nasal cavity using 16S rRNA gene amplicon sequencing in PD subjects and compared it to that of spousal and non-spousal healthy controls. Correlations between microbial taxa and PD symptom severity were also explored. Olfactory microbial communities of PD individuals were more similar to those of their spousal controls than to non-household controls. In direct comparison of PD and spousal controls and of PD and non-spousal controls, significantly differently abundant taxa were identified, and this included increased relative abundance of putative opportunistic-pathobiont species such as Moraxella catarrhalis. M. catarrhalis was also significantly correlated with more severe motor scores in PD subjects. This proof-of-concept study provides evidence that potential pathobionts are detected in the olfactory bulb and that a subset of changes in the PD microbiota community could be a consequence of unique environmental factors associated with PD living. We hypothesize that an altered deep nasal microbiota, characterized by a putative pro-inflammatory microbial community, could trigger neuroinflammation in PD.

© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.

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