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ACS Nano. 2021 Dec 28;15(12):19175-19184. doi: 10.1021/acsnano.1c03375. Epub 2021 Dec 09.

Tantalum Oxide Nanoparticles for the Quantitative Contrast-Enhanced Computed Tomography of .

ACS nano

Taylor Lawson, Anisha Joenathan, Amit Patwa, Brian D Snyder, Mark W Grinstaff

Affiliations

  1. Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, United States.
  2. Department of Mechanical Engineering, Boston University, Boston, Massachusetts 02215, United States.
  3. Division of Material Science, Boston University, Boston, Massachusetts 02215, United States.
  4. Department of Chemistry, School of Science, Navrachana University, Vadodara, Gujarat 391410, India.
  5. Department of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02215, United States.
  6. Department of Biomedical Engineering, Boston University, Boston, Massachusetts 02215, United States.
  7. Department of Medicine, Boston University, Boston, Massachusetts 02215 United States.

PMID: 34882411 DOI: 10.1021/acsnano.1c03375

Abstract

Nanoparticle-based contrast agents, when used in concert with imaging modalities such as computed tomography (CT), enhance the visualization of tissues and boundary interfaces. However, the ability to determine the physiological state of the tissue via the quantitative assessment of biochemical or biomechanical properties remains elusive. We report the synthesis and characterization of tantalum oxide (Ta

Keywords: computed tomography; contrast agent; imaging; nanoparticles; osteoarthritis

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