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Cavalieri S, Ronchi S, Barcellini A, et al. Toxicity of carbon ion radiotherapy and immune checkpoint inhibitors in advanced melanoma. Radiother Oncol. 2021;164:1-5doi: 10.1016/j.radonc.2021.08.021.
Cavalieri, S., Ronchi, S., Barcellini, A., Bonora, M., Vischioni, B., Vitolo, V., Villa, R., Del Vecchio, M., Licitra, L., & Orlandi, E. (2021). Toxicity of carbon ion radiotherapy and immune checkpoint inhibitors in advanced melanoma. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1641-5. https://doi.org/10.1016/j.radonc.2021.08.021
Cavalieri, Stefano, et al. "Toxicity of carbon ion radiotherapy and immune checkpoint inhibitors in advanced melanoma." Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology vol. 164 (2021): 1-5. doi: https://doi.org/10.1016/j.radonc.2021.08.021
Cavalieri S, Ronchi S, Barcellini A, Bonora M, Vischioni B, Vitolo V, Villa R, Del Vecchio M, Licitra L, Orlandi E. Toxicity of carbon ion radiotherapy and immune checkpoint inhibitors in advanced melanoma. Radiother Oncol. 2021 Nov;164:1-5. doi: 10.1016/j.radonc.2021.08.021. Epub 2021 Sep 08. PMID: 34506831.
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Radiother Oncol. 2021 Nov;164:1-5. doi: 10.1016/j.radonc.2021.08.021. Epub 2021 Sep 08.

Toxicity of carbon ion radiotherapy and immune checkpoint inhibitors in advanced melanoma.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

Stefano Cavalieri, Sara Ronchi, Amelia Barcellini, Maria Bonora, Barbara Vischioni, Viviana Vitolo, Riccardo Villa, Michele Del Vecchio, Lisa Licitra, Ester Orlandi

Affiliations

  1. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  2. Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy. Electronic address: [email protected].
  3. Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy.
  4. Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
  5. Head and Neck Medical Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy; Department of Oncology and Hemato-Oncology, University of Milan, Italy.

PMID: 34506831 DOI: 10.1016/j.radonc.2021.08.021

Abstract

We analyzed CTCAE adverse events of sequential Carbon Ion radiotherapy (CIRT) and immune checkpoint inhibitors (ICIs) in advanced melanoma patients. The frequencies of early and late adverse events (AEs) were 100% and 82% of patients, respectively. The frequency of G3+ AEs was in line with the literature.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Adverse events; Carbon ion radiotherapy; Carbon ion radiotherapy and immunotherapy combination; Immune checkpoint inhibitors; Mucosal melanoma

Conflict of interest statement

Conflict of interest statement Stefano Cavalieri, Sara Ronchi, Amelia Barcellini, Maria Bonora, Barbara Vischioni, Viviana Vitolo, Riccardo Villa and Ester Orlandi declare no conflict of interest. Mic

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