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Dupont J, Antonio L, Dedeyne L, et al. Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years). J Cachexia Sarcopenia Muscle. 2021;12(6):1818-1831doi: 10.1002/jcsm.12785.
Dupont, J., Antonio, L., Dedeyne, L., O'Neill, T. W., Vanderschueren, D., Rastrelli, G., Maggi, M., Bártfai, G., Casanueva, F. F., Giwercman, A., Słowikowska-Hilczer, J., Punab, M., Huhtaniemi, I. T., Wu, F. C. W., Tournoy, J., Koppo, K., & Gielen, E. (2021). Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years). Journal of cachexia, sarcopenia and muscle, 12(6), 1818-1831. https://doi.org/10.1002/jcsm.12785
Dupont, Jolan, et al. "Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years)." Journal of cachexia, sarcopenia and muscle vol. 12,6 (2021): 1818-1831. doi: https://doi.org/10.1002/jcsm.12785
Dupont J, Antonio L, Dedeyne L, O'Neill TW, Vanderschueren D, Rastrelli G, Maggi M, Bártfai G, Casanueva FF, Giwercman A, Słowikowska-Hilczer J, Punab M, Huhtaniemi IT, Wu FCW, Tournoy J, Koppo K, Gielen E. Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years). J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1818-1831. doi: 10.1002/jcsm.12785. Epub 2021 Sep 15. PMID: 34523822.
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J Cachexia Sarcopenia Muscle. 2021 Dec;12(6):1818-1831. doi: 10.1002/jcsm.12785. Epub 2021 Sep 15.

Inflammatory markers are associated with quality of life, physical activity, and gait speed but not sarcopenia in aged men (40-79 years).

Journal of cachexia, sarcopenia and muscle

Jolan Dupont, Leen Antonio, Lenore Dedeyne, Terence W O'Neill, Dirk Vanderschueren, Giulia Rastrelli, Mario Maggi, György Bártfai, Felipe F Casanueva, Aleksander Giwercman, Jolanta Słowikowska-Hilczer, Margus Punab, Ilpo T Huhtaniemi, Frederick C W Wu, Jos Tournoy, Katrien Koppo, Evelien Gielen

Affiliations

  1. Geriatrics and Gerontology, Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium.
  2. Department of Geriatric Medicine, UZ Leuven, Leuven, Belgium.
  3. Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven, Belgium.
  4. Centre for Epidemiology Versus Arthritis, The University of Manchester, NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester, UK.
  5. Andrology, Women's Endocrinology and Gender Incongruence Unit, Mario Serio 'Department of Experimental and Clinical Biomedical Sciences', University of Florence, Florence, Italy.
  6. Endocrinology Unit, Mario Serio 'Department of Experimental and Clinical Biomedical Sciences', University of Florence, Florence, Italy.
  7. Department of Obstetrics, Gynaecology and Andrology, Albert Szent-Györgyi Medical University, Szeged, Hungary.
  8. Department of Medicine, Santiago de Compostela University, Complejo Hospitalario Universitario de Santiago (CHUS), Santiago, Spain.
  9. CIBER de Fisiopatología Obesidad y Nutricion (CB06/03), Instituto Salud Carlos III, Santiago de Compostela, Santiago, Spain.
  10. Department of Translational Medicine, Lund University, Malmö, Sweden.
  11. Department of Andrology and Reproductive Endocrinology, Medical University of Lodz, ?ód?, Poland.
  12. Andrology Unit, United Laboratories of Tartu University Clinics, Tartu, Estonia.
  13. Department of Metabolism, Digestion and Reproduction, Institute of Reproductive and Developmental Biology, Imperial College London, London, UK.
  14. Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, University of Turku, Turku, Finland.
  15. Department of Endocrinology, Manchester Royal Infirmary, The University of Manchester, Manchester, UK.
  16. Exercise Physiology Research Group, Department of Movement Sciences, KU Leuven, Leuven, Belgium.

PMID: 34523822 DOI: 10.1002/jcsm.12785

Abstract

BACKGROUND: Age-related chronic low-grade inflammation (inflammaging) is one of the proposed mechanisms behind sarcopenia. However, findings regarding inflammatory markers in sarcopenic older adults are conflicting. This study aimed to determine the association between inflammatory markers, prevalent as well as incident sarcopenia, sarcopenia-defining parameters, quality of life (QoL), and physical activity in middle-aged and older men.

METHODS: Men aged 40-79 years (mean 59.66 ± 11.00y) were recruited from population registers in eight European centres for participation in the European Male Aging study (EMAS). Subjects were assessed at baseline (2003-2005) and again after a median follow-up of 4.29 years. In 2577 participants, associations between baseline inflammatory markers [high-sensitive C-reactive protein (hs-CRP), white blood cell count (WBC), albumin] and baseline physical activity (PASE) and QoL (SF-36) were analysed. In the Leuven and Manchester cohort (n = 447), data were available on muscle mass (whole-body dual X-ray absorptiometry) and strength. In this subgroup, cross-sectional associations between baseline inflammatory markers and sarcopenia-defining parameters (handgrip strength, chair stand test, appendicular lean mass, and gait speed) and prevalent sarcopenia were examined. In a further subgroup (n = 277), associations with knee extensor strength were explored. Longitudinally, predictive value of baseline inflammation on functional decline, physical activity, QoL, and incident sarcopenia was examined. Subgroup analyses were performed in subgroups with chronic inflammation and stratified by age. Linear and logistic regressions were used, adjusted for age, body mass index, centre, and smoking.

RESULTS: At baseline, hs-CRP and WBC were negatively associated with PASE score (hs-CRP: β = -7.920, P < 0.001; and WBC: β = -4.552, P < 0.001) and the physical component score of SF-36 (hs-CRP: β = -1.025, P < 0.001; and WBC: β = -0.364, P < 0.001). Baseline WBC levels were negatively associated with gait speed (β = -0.013; P = 0.025), quadriceps isometric 90° (β = -5.983; P = 0.035) and isokinetic 60°/s peak torque/body weight (β = -5.532; P = 0.027). The prevalence of sarcopenia at baseline was 18.1% (n = 81). Of those without sarcopenia at baseline, 64 (18.6%) satisfied criteria for sarcopenia at follow-up. There were no significant associations between baseline inflammatory markers and either prevalent or incident sarcopenia, or change in level of sarcopenia-defining parameters between baseline and follow-up.

CONCLUSIONS: In middle-aged and older men, hs-CRP and WBC were negatively associated with QoL and PASE scores, while WBC was negatively associated with gait speed and knee strength. Associations with hs-CRP remained significant in all ages, whereas WBC levels were only associated with PASE, gait speed and knee strength in older adults (60-79 years). Baseline inflammatory markers (hs-CRP, WBC and albumin) did not predict functional decline, decline in physical activity, decreased QoL or incident sarcopenia.

© 2021 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.

Keywords: Ageing; Inflammaging; Inflammation; Muscle strength; Older adult; Sarcopenia

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