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Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211038682. doi: 10.1177/10760296211038682.

Meta-analysis of Different Pressing Time on the Incidence of Subcutaneous Hemorrhage of Low Molecular Weight Heparin Administration.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Juan Fang, Gefeng Pan, Xufei Bao, Yanhong Wang

Affiliations

  1. 584020Zhejiang Hospital, Hangzhou, Zhejiang, P.R. China.

PMID: 34541913 PMCID: PMC8642065 DOI: 10.1177/10760296211038682

Abstract

To investigate the effect of different pressing time on the incidence of subcutaneous hemorrhage of low molecular weight heparin (LMWH) administration by meta-analysis. Cochrane Library, PubMed, MEDLINE, CINAHL, EMbase, Springer, EBSCO, China Biomedical Literature Database, CNKI, Wanfang Database, and VIP Database were searched. To screen the literature of randomized controlled trials with different pressing time in patients with subcutaneous LMWH injection from the establishment of the database to December 2020. The quality of the literature was evaluated and the data were extracted. Meta-analysis was performed by RevMan 5.3. A total of 17 randomized controlled trials were included. Meta-analysis showed that the bleeding rate of pressing for 5 min odds ratio (OR  =  3.89, 95% confidence interval [CI]: 2.68-5.64,

Keywords: low molecular weight heparin; meta-analysis; pressing time; subcutaneous hemorrhage; subcutaneous injection

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