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Carnevale JA, Goldberg JL, Schwartz T. Seizure in Patient with Neurofibromatosis and Amygdala Low-Grade Glioma. World Neurosurg. 2021;157:54-55doi: 10.1016/j.wneu.2021.09.097.
Carnevale, J. A., Goldberg, J. L., & Schwartz, T. (2022). Seizure in Patient with Neurofibromatosis and Amygdala Low-Grade Glioma. World neurosurgery, 15754-55. https://doi.org/10.1016/j.wneu.2021.09.097
Carnevale, Joseph A, et al. "Seizure in Patient with Neurofibromatosis and Amygdala Low-Grade Glioma." World neurosurgery vol. 157 (2022): 54-55. doi: https://doi.org/10.1016/j.wneu.2021.09.097
Carnevale JA, Goldberg JL, Schwartz T. Seizure in Patient with Neurofibromatosis and Amygdala Low-Grade Glioma. World Neurosurg. 2022 Jan;157:54-55. doi: 10.1016/j.wneu.2021.09.097. Epub 2021 Sep 29. PMID: 34600159.
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World Neurosurg. 2022 Jan;157:54-55. doi: 10.1016/j.wneu.2021.09.097. Epub 2021 Sep 29.

Seizure in Patient with Neurofibromatosis and Amygdala Low-Grade Glioma.

World neurosurgery

Joseph A Carnevale, Jacob L Goldberg, Theodore Schwartz

Affiliations

  1. Department of Neurological Surgery, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York, USA. Electronic address: [email protected].
  2. Department of Neurological Surgery, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, New York, USA.

PMID: 34600159 DOI: 10.1016/j.wneu.2021.09.097

Abstract

A 31-year-old male with history of bipolar disorder, suicidal attempts requiring inpatient hospitalization, and seizures on antiepileptic medications presented with increasing seizure frequency. He was neurologically intact yet had multiple facial, axillary, and inguinal flat pigmented macules (cafe au lait spots) and ophthalmologic examination with iris hamartomas (Lisch nodules) consistent with neurofibromatosis type 1. Electroencephalogram was notable for multiple right temporal lobe seizures with anterior temporal interictal epileptiform discharges. Magnetic resonance imaging revealed a T2 hyperintense mass centered in the right amygdala, contiguous with the cystic area. Preoperative intracarotid sodium amobarbital testing showed left-sided language and memory dominance. The patient was operated on for right amygdalohippocampectomy, and initial pathology was consistent with a low-grade neuroepithelial neoplastic process. Further pathologic examination found hypercellular proliferation of predominantly bland, spindled cells with scattered, embedded neurocytic elements with dysplastic appearance, consistent with low-grade glioma. The patient was clinically diagnosed with neurofibromatosis type 1.

Copyright © 2021 Elsevier Inc. All rights reserved.

Keywords: Epilepsy; Glioma; Neurofibromatosis; Seizure

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