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Li J, Liu X, Chen M, et al. Values of serum CA125, NSE and 24-hour urine VMA in diagnosis and prediction of treatment of paediatric neuroblastoma. Int J Clin Pract. 2021;75(12):e14932doi: 10.1111/ijcp.14932.
Li, J., Liu, X., Chen, M., Wang, J., & Wang, X. (2021). Values of serum CA125, NSE and 24-hour urine VMA in diagnosis and prediction of treatment of paediatric neuroblastoma. International journal of clinical practice, 75(12), e14932. https://doi.org/10.1111/ijcp.14932
Li, Jinmin, et al. "Values of serum CA125, NSE and 24-hour urine VMA in diagnosis and prediction of treatment of paediatric neuroblastoma." International journal of clinical practice vol. 75,12 (2021): e14932. doi: https://doi.org/10.1111/ijcp.14932
Li J, Liu X, Chen M, Wang J, Wang X. Values of serum CA125, NSE and 24-hour urine VMA in diagnosis and prediction of treatment of paediatric neuroblastoma. Int J Clin Pract. 2021 Dec;75(12):e14932. doi: 10.1111/ijcp.14932. Epub 2021 Oct 15. PMID: 34606672.
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Int J Clin Pract. 2021 Dec;75(12):e14932. doi: 10.1111/ijcp.14932. Epub 2021 Oct 15.

Values of serum CA125, NSE and 24-hour urine VMA in diagnosis and prediction of treatment of paediatric neuroblastoma.

International journal of clinical practice

Jinmin Li, Xiangyang Liu, Mo Chen, Jiachen Wang, Xinning Wang

Affiliations

  1. Pediatric Surgery Department, Cangzhou Central Hospital, Children's Hospital District, Cangzhou, China.
  2. Disinfection & Supply Department, Cangzhou Central Hospital, Cangzhou, China.

PMID: 34606672 DOI: 10.1111/ijcp.14932

Abstract

BACKGROUND: Paediatric neuroblastoma is a relatively common type of malignant tumour originating from neural crest tissues. Early diagnosis and the performance of specific therapeutic strategies can increase the survival rate and improve the prognosis of children with neuroblastoma.

METHODS: A total of 86 children with neuroblastoma were recruited in this research, and 50 healthy children aged 1-12 years were also selected as controls. Twenty-four-hour urine vanillylmandelic acid (VMA) was evaluated by high-performance liquid chromatography. Serum carbohydrate antigen 125 CA125 and neuron-specific enolase (NSE) levels were evaluated by electrochemiluminescence in Cobas E411 autoanalyser.

RESULTS: The serum CA125, NSE and 24-hour urine VMA levels of children with stage III-IVs neuroblastoma were significantly higher than those of children with clinical stages I-II; the serum CA125, NSE and 24-hour urine VMA levels of children in the effective treatment group were significantly lower than those in the treatment-ineffective group. The serum CA125 generated sensitivity and specificity of 71.88% and 59.26%, combined with an AUC (area under the curve) of 0.7049. The serum NSE generated sensitivity and specificity of 68.75% and 81.48%, combined with an AUC of 0.7407. The 24-hour urine VMA generated sensitivity and specificity of 90.63% and 59.26%, combined with an AUC of 0.7986.

CONCLUSION: In conclusion, serum CA125, NSE and 24-hour urine VMA levels before treatment could assess the condition of children with neuroblastoma and predict the effect of treatment.

© 2021 John Wiley & Sons Ltd.

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