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García-Villaseñor E, Bojalil-Álvarez L, Murrieta-Álvarez I, et al. Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype. Clin Appl Thromb Hemost. 2021;27:10760296211044212doi: 10.1177/10760296211044212.
García-Villaseñor, E., Bojalil-Álvarez, L., Murrieta-Álvarez, I., Cantero-Fortiz, Y., Ruiz-Delgado, G. J., & Ruiz-Argüelles, G. J. (2021). Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2710760296211044212. https://doi.org/10.1177/10760296211044212
García-Villaseñor, Elizabeth, et al. "Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype." Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis vol. 27 (2021): 10760296211044212. doi: https://doi.org/10.1177/10760296211044212
García-Villaseñor E, Bojalil-Álvarez L, Murrieta-Álvarez I, Cantero-Fortiz Y, Ruiz-Delgado GJ, Ruiz-Argüelles GJ. Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype. Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211044212. doi: 10.1177/10760296211044212. PMID: 34617458; PMCID: PMC8674482.
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Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211044212. doi: 10.1177/10760296211044212.

Primary Thrombophilia XVI: A Look at the Genotype of the Sticky Platelet Syndrome Phenotype.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

Elizabeth García-Villaseñor, Lorena Bojalil-Álvarez, Iván Murrieta-Álvarez, Yahveth Cantero-Fortiz, Guillermo J Ruiz-Delgado, Guillermo J Ruiz-Argüelles

Affiliations

  1. Centro de Hematología y Medicina Interna de Puebla, Puebla, México.
  2. 3972Benemérita Universidad Autónoma de Puebla, Puebla, México.
  3. 27861Universidad Popular Autónoma del Estado de Puebla, Puebla, México.
  4. 27806Universidad de las Américas Puebla, Puebla, México.
  5. 56079Laboratorios Clínicos de Puebla, Puebla, México.

PMID: 34617458 PMCID: PMC8674482 DOI: 10.1177/10760296211044212

Abstract

The sticky platelet syndrome (SPS) was described by Mammen in 1983. Since then, scientists in several countries have identified the condition and published cases or series of patients, thus enabling the description of the prevalence of the inherited condition, its salient clinical features, and the treatment of the disease. The diagnosis of the SPS phenotype requires fresh blood samples and special equipment which is not available in all coagulation laboratories. In the era of molecular biology, up to now it has not been possible to define a clear association of the SPS phenotype with a specific molecular marker. Some molecular changes which have been described in platelet proteins in some persons with the phenotype of the SPS are here discussed. Nowadays, the SPS phenotype may be considered as a risk factor for thrombosis and most cases of the SPS developing vaso-occlussive episodes are the result of its coexistence with other thrombosis-prone conditions, some of the inherited and some of them acquired, thus leading to the concept of multifactorial thrombophilia. Ignoring all these evidence-based concepts is inappropriate, same as stating that the SPS is a nonentity simply because not all laboratories are endowed with adequate equipment to support the diagnosis.

Keywords: hyperaggregability; platelets; thrombophilia; thrombosis

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