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Tissue Eng Part B Rev. 2021 Dec 30; doi: 10.1089/ten.TEB.2021.0120. Epub 2021 Dec 30.

Extracellular Matrix-Derived Hydrogels to Augment Dermal Wound Healing: A Systematic Review.

Tissue engineering. Part B, Reviews

Linda Vriend, Viktor Sinkunas, Cristina P Camargo, Berend van der Lei, Martin C Harmsen, Joris A van Dongen

Affiliations

  1. Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  2. Department of Plastic Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  3. Instituto do Coração (InCor), Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
  4. Plastic Surgery Laboratory, Department of Plastic Surgery and Microsurgery, University of São Paulo, São Paulo, Brazil.
  5. Bey Bergman Clinics, Hilversum, The Netherlands.
  6. Department of Plastic Surgery, University of Utrecht, University Medical Center Utrecht, Utrecht, The Netherlands.

PMID: 34693732 DOI: 10.1089/ten.TEB.2021.0120

Abstract

Chronic, non-healing, dermal wounds form a worldwide medical problem with limited and inadequate treatment options and high societal burden and costs. With the advent of regenerative therapies exploiting extracellular matrix (ECM) components, its efficacy to augment wound healing is to be explored. This systematic review was performed to assess and compare the current therapeutic efficacy of ECM hydrogels on dermal wound healing. The electronic databases of Embase, Medline Ovid, and Cochrane Central were searched for

Keywords: angiogenesis; extracellular matrix; hydrogels; wound healing

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