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Levy ME, Waters A, Sen S, et al. Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV. PLoS One. 2021;16(12):e0261746doi: 10.1371/journal.pone.0261746.
Levy, M. E., Waters, A., Sen, S., Castel, A. D., Plankey, M., Molock, S., Asch, F., Goparaju, L., & Kassaye, S. (2021). Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV. PloS one, 16(12), e0261746. https://doi.org/10.1371/journal.pone.0261746
Levy, Matthew E, et al. "Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV." PloS one vol. 16,12 (2021): e0261746. doi: https://doi.org/10.1371/journal.pone.0261746
Levy ME, Waters A, Sen S, Castel AD, Plankey M, Molock S, Asch F, Goparaju L, Kassaye S. Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV. PLoS One. 2021 Dec 23;16(12):e0261746. doi: 10.1371/journal.pone.0261746. eCollection 2021. PMID: 34941922; PMCID: PMC8699620.
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PLoS One. 2021 Dec 23;16(12):e0261746. doi: 10.1371/journal.pone.0261746. eCollection 2021.

Psychosocial stress and neuroendocrine biomarker concentrations among women living with or without HIV.

PloS one

Matthew E Levy, Ansley Waters, Sabyasachi Sen, Amanda D Castel, Michael Plankey, Sherry Molock, Federico Asch, Lakshmi Goparaju, Seble Kassaye

Affiliations

  1. Department of Epidemiology, Milken Institute School of Public Health at the George Washington University, Washington, DC, United States of America.
  2. Westat, Rockville, Maryland, United States of America.
  3. Division of Clinical Epidemiology, Office of Epidemiology, Virginia Department of Health, Richmond, Virginia, United States of America.
  4. Division of Endocrinology, George Washington University School of Medicine and Health Sciences, Washington, DC, United States of America.
  5. Department of Medicine, Georgetown University Medical Center, Washington, DC, United States of America.
  6. Department of Psychology, The George Washington University, Washington, DC, United States of America.
  7. Cardiovascular Core Laboratories and Cardiac Imaging Research, MedStar Health Research Institute, MedStar Heart and Vascular Institute, Washington, DC, United States of America.

PMID: 34941922 PMCID: PMC8699620 DOI: 10.1371/journal.pone.0261746

Abstract

OBJECTIVE: Women living with HIV (WLWH) experience psychosocial stress related to social-structural vulnerabilities. To investigate neuroendocrine pathways linking stress and increased cardiovascular disease risk among WLWH, we evaluated associations between psychosocial stress (i.e., perceived stress, posttraumatic stress, and experiences of race- and gender-based harassment) and a composite neuroendocrine biomarker index among WLWH and women without HIV.

METHODS: In 2019-2020, Women's Interagency HIV Study participants in Washington, DC completed a questionnaire and provided blood and 12-hour overnight urine samples for testing of serum dehydroepiandrosterone sulfate (DHEA-S) and urinary free cortisol, epinephrine, and norepinephrine. Psychosocial stress was measured using the Perceived Stress Scale, PTSD Checklist-Civilian Version, and Racialized Sexual Harassment Scale. Latent profile analysis was used to classify participants into low (38%), moderate (44%), and high (18%) stress groups. Composite biomarker index scores between 0-4 were assigned based on participants' number of neuroendocrine biomarkers in high-risk quartiles (≥75th percentile for cortisol, epinephrine, and norepinephrine and ≤25th percentile for DHEA-S). We evaluated associations between latent profile and composite biomarker index values using multivariable linear regression, adjusting for socio-demographic, behavioral, metabolic, and HIV-related factors.

RESULTS: Among 90 women, 62% were WLWH, 53% were non-Hispanic Black, and median age was 55 years. In full multivariable models, there was no statistically significant association between psychosocial stress and composite biomarker index values among all women independent of HIV status. High (vs. low) psychosocial stress was positively associated with higher mean composite biomarker index values among all monoracial Black women (adjusted β = 1.32; 95% CI: 0.20-2.43), Black WLWH (adjusted β = 1.93; 95% CI: 0.02-3.83) and Black HIV-negative women (adjusted β = 2.54; 95% CI: 0.41-4.67).

CONCLUSIONS: Despite a null association in the overall sample, greater psychosocial stress was positively associated with higher neuroendocrine biomarker concentrations among Black women, highlighting a plausible mechanism by which psychosocial stress could contribute to cardiovascular disease risk.

Conflict of interest statement

One of the authors [ML] is currently affiliated with a commercial entity, Westat. Data collection and analysis for this study occurred prior to his current affiliation with Westat, while he was affili

References

  1. Am J Cardiol. 2016 Jan 15;117(2):214-20 - PubMed
  2. Eur Heart J. 2012 May;33(9):1058-66 - PubMed
  3. J Stud Alcohol Drugs. 2017 Nov;78(6):930-937 - PubMed
  4. Am J Public Health. 2012 Jul;102(7):1267-73 - PubMed
  5. J Clin Endocrinol Metab. 2010 Nov;95(11):4959-64 - PubMed
  6. Curr Cardiovasc Risk Rep. 2014 Jan 1;8(1):365 - PubMed
  7. N Engl J Med. 1986 Dec 11;315(24):1519-24 - PubMed
  8. Soc Sci Med. 2013 Jun;87:147-54 - PubMed
  9. Psychosom Med. 2018 Feb/Mar;80(2):208-215 - PubMed
  10. Neurosci Biobehav Rev. 2010 Sep;35(1):2-16 - PubMed
  11. J Epidemiol Community Health. 2006 Jul;60(7):633-9 - PubMed
  12. Metabolism. 2002 Jun;51(6 Suppl 1):5-10 - PubMed
  13. AIDS. 2009 Jun 1;23(9):1059-67 - PubMed
  14. Am Heart J. 2013 Nov;166(5):806-14 - PubMed
  15. J Behav Med. 2018 Apr;41(2):208-220 - PubMed
  16. J Am Heart Assoc. 2014 Oct 16;3(5):e001035 - PubMed
  17. J HIV AIDS Soc Serv. 2015;14(2):188-205 - PubMed
  18. Soc Sci Med. 2008 Feb;66(3):507-19; discussion 520-35 - PubMed
  19. Clin Diagn Lab Immunol. 2005 Sep;12(9):1013-9 - PubMed
  20. Ann Epidemiol. 2015 Feb;25(2):84-9 - PubMed
  21. AIDS Patient Care STDS. 2013 Feb;27(2):114-22 - PubMed
  22. Am J Public Health. 2013 Aug;103(8):1476-84 - PubMed
  23. Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1476-98 - PubMed
  24. Am Psychol. 2013 May-Jun;68(4):197-209 - PubMed
  25. Sports Med. 2014 Jan;44(1):81-121 - PubMed
  26. PLoS Med. 2011 Nov;8(11):e1001124 - PubMed
  27. AIDS Behav. 2020 Jun;24(6):1653-1662 - PubMed
  28. J Acquir Immune Defic Syndr. 2020 Apr 15;83(5):441-449 - PubMed
  29. Psychosom Med. 2018 Feb/Mar;80(2):160-166 - PubMed
  30. AIDS Behav. 2010 Apr;14(2):339-50 - PubMed
  31. Cultur Divers Ethnic Minor Psychol. 2014 Oct;20(4):561-9 - PubMed
  32. J Health Soc Behav. 1983 Dec;24(4):385-96 - PubMed
  33. J Atheroscler Thromb. 2014;21(5):391-401 - PubMed
  34. Ethn Health. 2021 Apr;26(3):413-430 - PubMed
  35. Psychoneuroendocrinology. 2016 Jan;63:271-5 - PubMed
  36. AIDS Care. 2016 Dec;28(12):1551-1558 - PubMed
  37. Ann Epidemiol. 2012 Feb;22(2):104-11 - PubMed
  38. Psychosom Med. 2006 Sep-Oct;68(5):692-7 - PubMed
  39. ANS Adv Nurs Sci. 2014 Oct-Dec;37(4):287-98 - PubMed
  40. Epidemiology. 1998 Mar;9(2):117-25 - PubMed
  41. J Am Heart Assoc. 2020 Jul 7;9(13):e016425 - PubMed
  42. AIDS Behav. 2012 Nov;16(8):2144-59 - PubMed
  43. Circulation. 2018 Sep 11;138(11):1100-1112 - PubMed
  44. AIDS Patient Care STDS. 2015 Nov;29(11):606-16 - PubMed
  45. J Behav Med. 2017 Aug;40(4):539-552 - PubMed
  46. Psychosom Med. 2020 Apr;82(3):316-323 - PubMed
  47. J Gerontol B Psychol Sci Soc Sci. 2010 Sep;65(5):513-25 - PubMed
  48. Cultur Divers Ethnic Minor Psychol. 2008 Oct;14(4):307-14 - PubMed
  49. Int J Epidemiol. 2018 Apr 1;47(2):393-394i - PubMed
  50. AIDS Behav. 2012 Nov;16(8):2091-100 - PubMed
  51. Clin Infect Dis. 2020 Jul 27;71(3):491-498 - PubMed
  52. AIDS. 2010 May 15;24(8):1228-30 - PubMed
  53. AIDS Patient Care STDS. 2019 Apr;33(4):175-183 - PubMed
  54. Psychoneuroendocrinology. 2019 Jan;99:225-235 - PubMed
  55. Psychoneuroendocrinology. 2002 Oct;27(7):805-19 - PubMed
  56. Psychosom Med. 2012 Nov-Dec;74(9):896-903 - PubMed
  57. J Couns Psychol. 2017 Oct;64(5):475-486 - PubMed
  58. AIDS. 2002;16 Suppl 4:S69-76 - PubMed
  59. J Clin Epidemiol. 2002 Jul;55(7):696-710 - PubMed
  60. Cult Health Sex. 2017 Dec;19(12):1329-1343 - PubMed
  61. Stress. 2009 Jan;12(1):37-48 - PubMed
  62. Psychoneuroendocrinology. 2015 Oct;60:120-9 - PubMed
  63. Curr Opin HIV AIDS. 2017 Nov;12(6):585-593 - PubMed
  64. J Womens Health (Larchmt). 2014 Dec;23(12):1039-45 - PubMed
  65. J Clin Endocrinol Metab. 2007 Jul;92(7):2506-12 - PubMed
  66. Sociol Perspect. 2013 Spring;56(1):25-48 - PubMed
  67. Scand J Work Environ Health. 2006 Dec;32(6):431-42 - PubMed
  68. Psychol Trauma. 2019 Oct;11(7):685-694 - PubMed
  69. Arch Gerontol Geriatr. 2020 Mar - Apr;87:104006 - PubMed
  70. Soc Sci Med. 2017 Nov;193:90-100 - PubMed
  71. Psychosom Med. 2018 Oct;80(8):733-741 - PubMed
  72. Psychol Women Q. 2015 Sep 1;39(3):287-304 - PubMed
  73. Nat Rev Cardiol. 2012 Apr 03;9(6):360-70 - PubMed
  74. N Engl J Med. 2002 Jan 10;346(2):108-14 - PubMed
  75. Am Heart J. 2012 Apr;163(4):677-83 - PubMed
  76. Soc Sci Med. 2014 Feb;103:42-50 - PubMed
  77. J Behav Med. 2013 Jun;36(3):283-94 - PubMed
  78. AIDS. 2016 Jun 19;30(10):1495-509 - PubMed
  79. Psychosom Med. 2020 Jan;82(1):99-107 - PubMed

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