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Gurevich E, Segev Y, Landau D. Growth Hormone and IGF1 Actions in Kidney Development and Function. Cells. 2021;10(12)doi: 10.3390/cells10123371.
Gurevich, E., Segev, Y., & Landau, D. (2021). Growth Hormone and IGF1 Actions in Kidney Development and Function. Cells, 10(12), . https://doi.org/10.3390/cells10123371
Gurevich, Evgenia, et al. "Growth Hormone and IGF1 Actions in Kidney Development and Function." Cells vol. 10,12 (2021). doi: https://doi.org/10.3390/cells10123371
Gurevich E, Segev Y, Landau D. Growth Hormone and IGF1 Actions in Kidney Development and Function. Cells. 2021 Nov 30;10(12). doi: 10.3390/cells10123371. PMID: 34943879; PMCID: PMC8699155.
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Cells. 2021 Nov 30;10(12). doi: 10.3390/cells10123371.

Growth Hormone and IGF1 Actions in Kidney Development and Function.

Cells

Evgenia Gurevich, Yael Segev, Daniel Landau

Affiliations

  1. Department of Nephrology, Schneider Children's Medical Center of Israel, 14 Kaplan Street, Petach Tikva 4920235, Israel.
  2. Shraga Segal Department of Microbiology and Immunology, Ben Gurion University, Beer Sheva 8410501, Israel.
  3. Sackler School of Medicine, Tel Aviv University, P.O. Box 39040, Tel Aviv 6997801, Israel.

PMID: 34943879 PMCID: PMC8699155 DOI: 10.3390/cells10123371

Abstract

Growth hormone (GH) exerts multiple effects on different organs including the kidneys, either directly or via its main mediator, insulin-like-growth factor-1 (IGF-1). The GH/IGF1 system plays a key role in normal kidney development, glomerular hemodynamic regulation, as well as tubular water, sodium, phosphate, and calcium handling. Transgenic animal models demonstrated that GH excess (and not IGF1) may lead to hyperfiltration, albuminuria, and glomerulosclerosis. GH and IGF-1 play a significant role in the early development of diabetic nephropathy, as well as in compensatory kidney hypertrophy after unilateral nephrectomy. Chronic kidney disease (CKD) and its complications in children are associated with alterations in the GH/IGF1 axis, including growth retardation, related to a GH-resistant state, attributed to impaired kidney postreceptor GH-signaling and chronic inflammation. This may explain the safety of prolonged rhGH-treatment of short stature in CKD.

Keywords: chronic kidney disease; diabetic nephropathy; growth hormone; growth hormone receptor; insulin-like growth factor 1; kidney hypertrophy; receptor signaling

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