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Ortiz Hidalgo C. Immunohistochemistry in Historical Perspective: Knowing the Past to Understand the Present. Methods Mol Biol. 2022;2422:17-31doi: 10.1007/978-1-0716-1948-3_2.
Ortiz Hidalgo, C. (2022). Immunohistochemistry in Historical Perspective: Knowing the Past to Understand the Present. Methods in molecular biology (Clifton, N.J.), 242217-31. https://doi.org/10.1007/978-1-0716-1948-3_2
Ortiz Hidalgo, Carlos. "Immunohistochemistry in Historical Perspective: Knowing the Past to Understand the Present." Methods in molecular biology (Clifton, N.J.) vol. 2422 (2022): 17-31. doi: https://doi.org/10.1007/978-1-0716-1948-3_2
Ortiz Hidalgo C. Immunohistochemistry in Historical Perspective: Knowing the Past to Understand the Present. Methods Mol Biol. 2022;2422:17-31. doi: 10.1007/978-1-0716-1948-3_2. PMID: 34859396.
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Methods Mol Biol. 2022;2422:17-31. doi: 10.1007/978-1-0716-1948-3_2.

Immunohistochemistry in Historical Perspective: Knowing the Past to Understand the Present.

Methods in molecular biology (Clifton, N.J.)

Carlos Ortiz Hidalgo

Affiliations

  1. Department of Anatomic Pathology, Fundación Clínica Médica Sur, Ciudad de México, Mexico. [email protected].
  2. Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Panamericana, Ciudad de México, Mexico. [email protected].

PMID: 34859396 DOI: 10.1007/978-1-0716-1948-3_2

Abstract

Immunohistochemistry is an extraordinary and extensively used technique whereby antibodies are used to detect antigens in cells within a tissue section. It has numerous applications in medicine, particularly in cancer diagnosis. It was Albert Hewett Coons, Hugh J Creech, Norman Jones, and Ernst Berliner who conceptualized and first implemented the procedure of immunofluorescence in 1941. They used fluorescein isothiocyanate (FITC)-labelled antibodies to localize pneumococcal antigens in infected tissues. Since then, with improvement and development of protein conjugation, enzyme labels have been introduced, such as peroxidase and alkaline phosphatase. The history of immunohistochemistry (IHC) combines physiology, immunology, biochemistry, and the work of various Nobel Prize laureates. From von Behring who was awarded de first Nobel Prize in 1901 for his work on serum therapy to the 1984 Nobel Prize for the discovery of monoclonal antibodies by Milstein, Kohler, and Jerne, IHC is a story of cooperation and collaboration which led to the development of this magnificent technique that is used daily in anatomical pathology laboratories worldwide.

© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Keywords: Antibodies; History; Hybridoma; Immunohistochemistry

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