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Jesus C, Soares R, Cunha E, et al. Influence of Nisin-Biogel at Subinhibitory Concentrations on Virulence Expression in . Antibiotics (Basel). 2021;10(12)doi: 10.3390/antibiotics10121501.
Jesus, C., Soares, R., Cunha, E., Grilo, M., Tavares, L., & Oliveira, M. (2021). Influence of Nisin-Biogel at Subinhibitory Concentrations on Virulence Expression in . Antibiotics (Basel, Switzerland), 10(12), . https://doi.org/10.3390/antibiotics10121501
Jesus, Carolina, et al. "Influence of Nisin-Biogel at Subinhibitory Concentrations on Virulence Expression in ." Antibiotics (Basel, Switzerland) vol. 10,12 (2021). doi: https://doi.org/10.3390/antibiotics10121501
Jesus C, Soares R, Cunha E, Grilo M, Tavares L, Oliveira M. Influence of Nisin-Biogel at Subinhibitory Concentrations on Virulence Expression in . Antibiotics (Basel). 2021 Dec 07;10(12). doi: 10.3390/antibiotics10121501. PMID: 34943712; PMCID: PMC8698857.
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Antibiotics (Basel). 2021 Dec 07;10(12). doi: 10.3390/antibiotics10121501.

Influence of Nisin-Biogel at Subinhibitory Concentrations on Virulence Expression in .

Antibiotics (Basel, Switzerland)

Carolina Jesus, Rui Soares, Eva Cunha, Miguel Grilo, Luís Tavares, Manuela Oliveira

Affiliations

  1. CIISA-Centro de Investigação Interdisciplinar em Sanidade Animal, Faculdade de Medicina Veterinária, Universidade de Lisboa, Avenida da Universidade Técnica, 1300-477 Lisboa, Portugal.

PMID: 34943712 PMCID: PMC8698857 DOI: 10.3390/antibiotics10121501

Abstract

A new approach to diabetic foot infections (DFIs) has been investigated, using a nisin-biogel combining the antimicrobial peptide (AMP) nisin with the natural polysaccharide guar-gum. Since in in vivo conditions bacteria may be exposed to decreased antimicrobial concentrations, known as subinhibitory concentrations (sub-MICs), effects of nisin-biogel sub-MIC values corresponding to 1/2, 1/4 and 1/8 of nisin's minimum inhibitory concentration (MIC) on virulence expression by six

Keywords: Staphylococcus aureus; biofilm; diabetic foot infections; subinhibitory concentrations; virulence-related genes

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