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Fésüs A, Benkő R, Matuz M, et al. The Effect of Pharmacist-Led Intervention on Surgical Antibacterial Prophylaxis (SAP) at an Orthopedic Unit. Antibiotics (Basel). 2021;10(12)doi: 10.3390/antibiotics10121509.
Fésüs, A., Benkő, R., Matuz, M., Kungler-Gorácz, O., Fésüs, M. �. �., Bazsó, T., Csernátony, Z., & Kardos, G. (2021). The Effect of Pharmacist-Led Intervention on Surgical Antibacterial Prophylaxis (SAP) at an Orthopedic Unit. Antibiotics (Basel, Switzerland), 10(12), . https://doi.org/10.3390/antibiotics10121509
Fésüs, Adina, et al. "The Effect of Pharmacist-Led Intervention on Surgical Antibacterial Prophylaxis (SAP) at an Orthopedic Unit." Antibiotics (Basel, Switzerland) vol. 10,12 (2021). doi: https://doi.org/10.3390/antibiotics10121509
Fésüs A, Benkő R, Matuz M, Kungler-Gorácz O, Fésüs MÁ, Bazsó T, Csernátony Z, Kardos G. The Effect of Pharmacist-Led Intervention on Surgical Antibacterial Prophylaxis (SAP) at an Orthopedic Unit. Antibiotics (Basel). 2021 Dec 09;10(12). doi: 10.3390/antibiotics10121509. PMID: 34943721.
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Antibiotics (Basel). 2021 Dec 09;10(12). doi: 10.3390/antibiotics10121509.

The Effect of Pharmacist-Led Intervention on Surgical Antibacterial Prophylaxis (SAP) at an Orthopedic Unit.

Antibiotics (Basel, Switzerland)

Adina Fésüs, Ria Benkő, Mária Matuz, Orsolya Kungler-Gorácz, Márton Á Fésüs, Tamás Bazsó, Zoltán Csernátony, Gábor Kardos

Affiliations

  1. Central Clinical Pharmacy, Clinical Center, University of Debrecen, H-4032 Debrecen, Hungary.
  2. Department of Pharmacodynamics, Faculty of Pharmacy, University of Debrecen, H-4032 Debrecen, Hungary.
  3. Doctoral School of Pharmaceutical Sciences, University of Debrecen, H-4032 Debrecen, Hungary.
  4. Clinical Pharmacy Department, Faculty of Pharmacy, University of Szeged, H-6725 Szeged, Hungary.
  5. Central Pharmacy, Albert Szent Györgyi Medical Center, University of Szeged, H-6725 Szeged, Hungary.
  6. Department of Emergency Medicine, Albert Szent Györgyi Medical Center, University of Szeged, H-6725 Szeged, Hungary.
  7. Department of Metagenomics, University of Debrecen, H-4032 Debrecen, Hungary.
  8. Department of Traumatology and Hand Surgery, Faculty of Medicine, University of Debrecen, H-4031 Debrecen, Hungary.
  9. Department of Orthopedic Surgery, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Hungary.

PMID: 34943721 DOI: 10.3390/antibiotics10121509

Abstract

Perioperative antibiotic use is a common reason for antibiotic misuse. Evidence suggests that adherence to SAP guidelines may improve outcomes. The purpose of this study was to analyze the impact of pharmacist-led antibiotic stewardship interventions on SAP guideline compliance. The study was conducted at an Orthopedic Department of a tertiary care medical center. SAP compliance and antibiotic exposure in the pre-intervention and intervention period was compared using chi-square, Fisher exact, and Mann-Whitney tests, as appropriate. Prophylactic antibiotic use in orthopedic joint arthroplasties (overall guideline adherence: agent, dose, frequency, duration), clinical outcomes (length of stay-LOS, number of surgical site infections-SSIs), antibiotic exposure and direct antibiotic costs were compared between pre-intervention and intervention periods. Significant improvement in mean SAP duration (by 42.9%, 4.08 ± 2.08 vs. 2.08 ± 1.90 days,

Keywords: antibiotic exposure; antibiotic stewardship consultation; cost of surgical antibacterial prophylaxis; surgical antibacterial prophylaxis; total hip arthroplasty; total knee arthroplasty

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