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Cells. 2021 Nov 30;10(12). doi: 10.3390/cells10123364.

Targeting CAMKK2 and SOC Channels as a Novel Therapeutic Approach for Sensitizing Acute Promyelocytic Leukemia Cells to All-Trans Retinoic Acid.

Cells

Faten Merhi, Karla Alvarez-Valadez, Jenifer Trepiana, Claire Lescoat, Alexis Groppi, Jean-William Dupuy, Pierre Soubeyran, Guido Kroemer, Pierre Vacher, Mojgan Djavaheri-Mergny

Affiliations

  1. Institut Bergonié, INSERM U1218, University of Bordeaux, 33000 Bordeaux, France.
  2. PRASE, Platform of Research and Analysis in Environmental Sciences, Doctoral School of Sciences and Technologies, Lebanese University, Hadat Campus, Beirut 1003, Lebanon.
  3. Centre de Recherche des Cordeliers, INSERM UMRS 1138, Sorbonne Université, Université de Paris, Équipe 11 labellisée par la Ligue Contre le Cancer, 75006 Paris, France.
  4. Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, 94805 Villejuif, France.
  5. Centre de Bioinformatique de Bordeaux (CBiB), University of Bordeaux, 33076 Bordeaux, France.
  6. University of Bordeaux, CNRS, IBGC, UMR 5095, 33077 Bordeaux, France.
  7. University of Bordeaux, Plateforme Protéome, 33076 Bordeaux, France.
  8. Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75015 Paris, France.

PMID: 34943872 DOI: 10.3390/cells10123364

Abstract

Calcium ions (Ca

Keywords: AMPK; ORAI1; STIM1; autophagy; cancer; cell death; differentiation; resistance to therapy; therapy

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