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Ahmed MN, Jahan R, Nissapatorn V, et al. Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies. Biomed Pharmacother. 2021;146:112507doi: 10.1016/j.biopha.2021.112507.
Ahmed, M. N., Jahan, R., Nissapatorn, V., Wilairatana, P., & Rahmatullah, M. (2021). Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 146112507. https://doi.org/10.1016/j.biopha.2021.112507
Ahmed, Md Nasir, et al. "Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies." Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie vol. 146 (2021): 112507. doi: https://doi.org/10.1016/j.biopha.2021.112507
Ahmed MN, Jahan R, Nissapatorn V, Wilairatana P, Rahmatullah M. Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies. Biomed Pharmacother. 2021 Dec 07;146:112507. doi: 10.1016/j.biopha.2021.112507. Epub 2021 Dec 07. PMID: 34891122; PMCID: PMC8648558.
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Biomed Pharmacother. 2021 Dec 07;146:112507. doi: 10.1016/j.biopha.2021.112507. Epub 2021 Dec 07.

Plant lectins as prospective antiviral biomolecules in the search for COVID-19 eradication strategies.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Md Nasir Ahmed, Rownak Jahan, Veeranoot Nissapatorn, Polrat Wilairatana, Mohammed Rahmatullah

Affiliations

  1. Department of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka, Bangladesh; Biotechnology & Natural Medicine Division, TechB Nutrigenomics, Dhaka, Bangladesh. Electronic address: [email protected].
  2. Department of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka, Bangladesh. Electronic address: [email protected].
  3. School of Allied Health Sciences and World Union for Herbal Drug Discovery (WUHeDD), Walailak University, Nakhon Si Thammarat, Thailand.
  4. Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Electronic address: [email protected].
  5. Department of Biotechnology & Genetic Engineering, University of Development Alternative, Dhaka, Bangladesh. Electronic address: [email protected].

PMID: 34891122 PMCID: PMC8648558 DOI: 10.1016/j.biopha.2021.112507

Abstract

Lectins or clusters of carbohydrate-binding proteins of non-immune origin are distributed chiefly in the Plantae. Lectins have potent anti-infectivity properties for several RNA viruses including SARS-CoV-2. The primary purpose of this review is to review the ability of lectins mediated potential biotherapeutic and bioprophylactic strategy against coronavirus causing COVID-19. Lectins have binding affinity to the glycans of SARS-COV-2 Spike glycoprotein that has N-glycosylation sites. Apart from this, the complement lectin pathway is a "first line host defense" against the viral infection that is activated by mannose-binding lectins. Mannose-binding lectins deficiency in serum influences innate immunity of the host and facilitates infectious diseases including COVID-19. Our accumulated evidence obtained from scientific databases particularly PubMed and Google Scholar databases indicate that mannose-specific/mannose-binding lectins (MBL) have potent efficacies like anti-infectivity, complement cascade induction, immunoadjuvants, DC-SIGN antagonists, or glycomimetic approach, which can prove useful in the strategy of COVID-19 combat along with the glycobiological aspects of SARS-CoV-2 infections and antiviral immunity. For example, plant-derived mannose-specific lectins BanLac, FRIL, Lentil, and GRFT from red algae can inhibit and neutralize SARS-CoV-2 infectivity, as confirmed with in-vitro, in-vivo, and in-silico assessments. Furthermore, Bangladesh has a noteworthy resource of antiviral medicinal plants as well as plant lectins. Intensifying research on the antiviral plant lectins, adopting a glyco-biotechnological approach, and with deeper insights into the "glycovirological" aspects may result in the designing of alternative and potent blueprints against the 21st century's biological pandemic of SARS-CoV-2 causing COVID-19.

Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.

Keywords: Antiviral plant lectins; Glycobiotechnology; Glycoprotein; Glycosylation; Mannose-specific/mannose-binding lectins; SARS-CoV-2 glycobiology

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