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Czarnecki D, Ziółkowski M, Chodkiewicz J, et al. Initial Study on COMT and DRD2 Gene Polymorphisms as Well as the Influence of Temperament and Character Trait on the Severity of Alcohol Craving in Alcohol-Dependent Patients. J Clin Med. 2021;10(24)doi: 10.3390/jcm10245892.
Czarnecki, D., Ziółkowski, M., Chodkiewicz, J., Długosz, A., Feldheim, J., Waszkiewicz, N., Kułak-Bejda, A., Gorzkiewicz, M., Budzyński, J., Junkiert-Czarnecka, A., Siomek-Górecka, A., Nicpoń, K., Kawala-Sterniuk, A., Ferri, R., Pelc, M., Walecki, P., Laskowska, E., & Gorzelańczyk, E. J. (2021). Initial Study on COMT and DRD2 Gene Polymorphisms as Well as the Influence of Temperament and Character Trait on the Severity of Alcohol Craving in Alcohol-Dependent Patients. Journal of clinical medicine, 10(24), . https://doi.org/10.3390/jcm10245892
Czarnecki, Damian, et al. "Initial Study on COMT and DRD2 Gene Polymorphisms as Well as the Influence of Temperament and Character Trait on the Severity of Alcohol Craving in Alcohol-Dependent Patients." Journal of clinical medicine vol. 10,24 (2021). doi: https://doi.org/10.3390/jcm10245892
Czarnecki D, Ziółkowski M, Chodkiewicz J, Długosz A, Feldheim J, Waszkiewicz N, Kułak-Bejda A, Gorzkiewicz M, Budzyński J, Junkiert-Czarnecka A, Siomek-Górecka A, Nicpoń K, Kawala-Sterniuk A, Ferri R, Pelc M, Walecki P, Laskowska E, Gorzelańczyk EJ. Initial Study on COMT and DRD2 Gene Polymorphisms as Well as the Influence of Temperament and Character Trait on the Severity of Alcohol Craving in Alcohol-Dependent Patients. J Clin Med. 2021 Dec 15;10(24). doi: 10.3390/jcm10245892. PMID: 34945190; PMCID: PMC8704345.
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J Clin Med. 2021 Dec 15;10(24). doi: 10.3390/jcm10245892.

Initial Study on COMT and DRD2 Gene Polymorphisms as Well as the Influence of Temperament and Character Trait on the Severity of Alcohol Craving in Alcohol-Dependent Patients.

Journal of clinical medicine

Damian Czarnecki, Marcin Ziółkowski, Jan Chodkiewicz, Anna Długosz, Joanna Feldheim, Napoleon Waszkiewicz, Agnieszka Kułak-Bejda, Marta Gorzkiewicz, Jacek Budzyński, Anna Junkiert-Czarnecka, Agnieszka Siomek-Górecka, Krzysztof Nicpoń, Aleksandra Kawala-Sterniuk, Raffaele Ferri, Mariusz Pelc, Piotr Walecki, Ewa Laskowska, Edward Jacek Gorzelańczyk

Affiliations

  1. Department of Preventive Nursing, Collegium Medicum, Nicolaus Copernicus University, Torun, ul. Ignacego ?ukasiewicza 1, 85-821 Bydgoszcz, Poland.
  2. Institute of Psychology, Department of Clinical Psychology and Psychopathology, University of Lodz, ul. Smugowa 10/12, 91-433 ?ód?, Poland.
  3. Faculty of Chemical Technology and Engineering, University of Science and Technology, ul. Seminaryjna 3, 85-326 Bydgoszcz, Poland.
  4. Department of Psychiatry, Medical University of Bia?ystok, pl. Brodowicza 1, 16-070 Choroszcz, Poland.
  5. Department of Molecular Genetics and Justice, Collegium Medicum, Nicolaus Copernicus University, Torun, ul. Marii Sk?odowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
  6. Department of Vascular and Internal Diseases, Nicolaus Copernicus University, Torun, ul. Ujejskiego 75, 85-168 Bydgoszcz, Poland.
  7. Department of Clinical Genetics, Nicolaus Copernicus University, Torun, ul. Marii Sk?odowskiej-Curie 9, 85-094 Bydgoszcz, Poland.
  8. Department of Clinical Biochemistry, Collegium Medicum, Nicolaus Copernicus University, Torun, ul. Kar?owicza 24, 85-092 Bydgoszcz, Poland.
  9. Faculty of Electrical Engineering, Automatic Control and Informatics, Opole University of Technology, ul. Prószkowska 76, 45-758 Opole, Poland.
  10. Oasi Research Institute IRCCS, Via C. Ruggero, 73, 94018 Troina, Italy.
  11. School of Computing and Mathematical Sciences, University of Greenwich, London SE10 9LS, UK.
  12. Department of Bioinformatics and Telemedicine, Collegium Medicum, Jagiellonian University, ul. Medyczna 7, 30-688 Krakow, Poland.
  13. Faculty of Medicine, Collegium Medicum, Nicolaus Copernicus University, Torun, ul. Jagiello?ska 15, 85-067 Bydgoszcz, Poland.
  14. Department of Theoretical Basis of BioMedical Sciences and Medical Informatics, Collegium Medicum, Nicolaus Copernicus University, ul. Jagiello?ska 15, 85-067 Bydgoszcz, Poland.
  15. Institute of Philosophy, Kazimierz Wielki University, ul. Ogi?skiego 16, 85-092 Bydgoszcz, Poland.
  16. Babinski Specialist Psychiatric Healthcare Center, Outpatient Addiction Treatment, ul. Aleksandrowska 159, 91-229 ?ód?, Poland.
  17. The Society for the Substitution Treatment of Addiction "Medically Assisted Recovery", ul. Rze?niackiego 1D, 85-791 Bydgoszcz, Poland.

PMID: 34945190 PMCID: PMC8704345 DOI: 10.3390/jcm10245892

Abstract

The main aim of this work was to determine the impact of COMT and DRD2 gene polymorphisms together with temperament and character traits on alcohol craving severity alcohol-dependent persons. The sample comprised of 89 men and 16 women (aged 38±7). For the sake of psychological assessment various analytic methods have been applied like the Short Alcohol Dependence Data Questionnaire (SADD), Penn Alcohol Craving Scale (PACS) or Temperament and Character Inventory (TCI) test. The SNP polymorphism of the analyzed genes was determined by Real Time PCR test. The results showed, that the COMT polymorphismmay have an indirected relationship with the intensity and changes in alcohol craving during abstinence. The DRD2 receptor gene polymorphisms are related with the intensity of alcohol craving. It seems that the character traits like "self-targeting", including "self-acceptance", are more closely related to the severity of alcohol craving and polymorphic changes in the DRD2 receptor than temperamental traits. Although this is a pilot study the obtained results appeared to be promising and clearly indicate the link betweengene polymorphisms alcohol craving and its severity.

Keywords: alcohol craving; cortico-subcortical loops; dependency; genetics; neurophilosphy; polymorphisms

References

  1. Neuropsychologia. 2014 Sep;62:48-54 - PubMed
  2. Curr Top Behav Neurosci. 2013;13:3-30 - PubMed
  3. Br J Pharmacol. 2020 Sep;177(17):3855-3864 - PubMed
  4. Bosn J Basic Med Sci. 2013 Aug;13(3):158-62 - PubMed
  5. Arch Gen Psychiatry. 1974 Apr;30(4):539-47 - PubMed
  6. J Psychoactive Drugs. 2020 Sep-Oct;52(4):366-376 - PubMed
  7. J Alcohol Drug Depend. 2013 Sep;1(6): - PubMed
  8. Addict Behav. 2021 Mar;114:106652 - PubMed
  9. Drug Alcohol Depend. 1994 Feb;34(3):175-80 - PubMed
  10. Neuropsychopharmacology. 2018 Apr;43(5):1032-1040 - PubMed
  11. Eur Psychiatry. 2000 Mar;15(2):79-89 - PubMed
  12. Psychiatry Res. 2014 Dec 15;220(1-2):513-8 - PubMed
  13. J Stud Alcohol Drugs. 2007 May;68(3):362-70 - PubMed
  14. Alcohol Clin Exp Res. 1999 Aug;23(8):1289-95 - PubMed
  15. Zh Evol Biokhim Fiziol. 2017 Jan;53(1):33-40 - PubMed
  16. Addiction. 2004 Apr;99(4):482-97 - PubMed
  17. Psychother Res. 2020 Feb;30(2):170-182 - PubMed
  18. Psychol Rev. 1984 Apr;91(2):251-68 - PubMed
  19. Alcohol Res Health. 1999;23(3):165-73 - PubMed
  20. Psychiatr Pol. 2011 May-Jun;45(3):325-35 - PubMed
  21. J Addict Dis. 2007;26(1):79-84 - PubMed
  22. J Addict Res Ther. 2016 Apr;5(2): - PubMed
  23. Int J Psychiatry Clin Pract. 2020 Jun;24(2):151-162 - PubMed
  24. Psychiatry Res. 2021 Jan;295:113563 - PubMed
  25. Neuropsychopharmacology. 2018 May;43(6):1247-1256 - PubMed
  26. Am Psychol. 2004 May-Jun;59(4):224-35 - PubMed
  27. Drug Alcohol Rev. 2012 Jan;31(1):81-90 - PubMed
  28. Alcohol Res Health. 1999;23(3):215-24 - PubMed
  29. Neuron. 2019 Aug 7;103(3):489-505.e7 - PubMed
  30. Neuroreport. 2002 Jul 2;13(9):1121-5 - PubMed
  31. Arch Gen Psychiatry. 1993 Dec;50(12):975-90 - PubMed
  32. J Clin Med. 2018 May 29;7(6): - PubMed
  33. Psicothema. 2011 Feb;23(1):100-6 - PubMed
  34. Pharmacol Biochem Behav. 2009 Sep;93(3):306-12 - PubMed
  35. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1;32(3):620-8 - PubMed
  36. Alcohol Alcohol. 2004 Jul-Aug;39(4):357-61 - PubMed
  37. Med Sci Monit. 2014 Mar 19;20:444-53 - PubMed
  38. Adicciones. 2008;20(2):143-8 - PubMed
  39. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Mar 2;106:110164 - PubMed
  40. Alcohol Res. 2020 Oct 29;40(2):01 - PubMed
  41. Alcohol Clin Exp Res. 2018 Jan;42(1):21-31 - PubMed
  42. J Addict Med. 2017 Mar/Apr;11(2):114-118 - PubMed
  43. Alcohol Clin Exp Res. 2005 Aug;29(8):1427-31 - PubMed
  44. Alcohol Res Health. 1999;23(3):197-206 - PubMed
  45. Arch Womens Ment Health. 2003 Nov;6(4):223-4 - PubMed
  46. Mol Psychiatry. 1997 May;2(3):239-46 - PubMed
  47. Handb Clin Neurol. 2014;125:355-68 - PubMed
  48. Neuropsychopharmacology. 2008 Jan;33(1):166-80 - PubMed
  49. BMC Psychiatry. 2003 Jan 13;3:1 - PubMed
  50. J Subst Abuse Treat. 2020 Dec;119:108127 - PubMed
  51. Addict Behav Rep. 2020 Oct 22;12:100308 - PubMed
  52. J Consult Clin Psychol. 2013 Feb;81(1):1-12 - PubMed
  53. Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6917-22 - PubMed
  54. Psychoneuroendocrinology. 2009 Aug;34(7):968-71 - PubMed
  55. Neurosci Lett. 2006 Dec 13;410(1):1-5 - PubMed
  56. Neuropsychobiology. 2002;45(3):128-30 - PubMed
  57. J Affect Disord. 2003 Dec;77(3):267-71 - PubMed
  58. Alcohol Alcohol. 1999 Mar-Apr;34(2):197-222 - PubMed
  59. Arch Womens Ment Health. 2003 Nov;6(4):253-8 - PubMed
  60. Neuropsychopharmacology. 2001 Feb;24(2):97-129 - PubMed
  61. Alcohol Alcohol. 2021 Jan 4;56(1):57-63 - PubMed
  62. Subst Use Misuse. 2019;54(13):2218-2228 - PubMed
  63. Psychiatr Pol. 2018 Jun 30;52(3):459-470 - PubMed
  64. J Neurochem. 2005 Apr;93(2):359-70 - PubMed
  65. Am J Psychiatry. 1999 Jan;156(1):11-8 - PubMed
  66. Med Hypotheses. 2007;69(5):1054-60 - PubMed
  67. Psychosom Med. 2011 Jan;73(1):23-8 - PubMed
  68. J Neuropsychiatry Clin Neurosci. 1990 Spring;2(2):123-44 - PubMed
  69. Science. 1997 Oct 3;278(5335):52-8 - PubMed
  70. Indian J Clin Biochem. 2021 Jul;36(3):257-265 - PubMed
  71. Alcohol. 2020 Mar;83:1-8 - PubMed
  72. Brain Res Brain Res Rev. 1993 Sep-Dec;18(3):247-91 - PubMed
  73. Encephale. 2000 Jan-Feb;26(1):68-78 - PubMed
  74. Psychotherapy (Chic). 2020 Sep;57(3):414-425 - PubMed
  75. Nutr Hosp. 2020 Jul 13;34(3):524-533 - PubMed
  76. Br J Addict. 1983 Mar;78(1):89-95 - PubMed
  77. Biol Psychiatry. 2008 Jul 15;64(2):137-44 - PubMed
  78. Genet Mol Biol. 2020 May 11;43(2):e20190380 - PubMed

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