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Ingrid BK, Nadine C. Mitophagy in Yeast: Decades of Research. Cells. 2021;10(12)doi: 10.3390/cells10123541.
Ingrid, B. K., & Nadine, C. (2021). Mitophagy in Yeast: Decades of Research. Cells, 10(12), . https://doi.org/10.3390/cells10123541
Ingrid, Bhatia-Kissova, and Nadine, Camougrand. "Mitophagy in Yeast: Decades of Research." Cells vol. 10,12 (2021). doi: https://doi.org/10.3390/cells10123541
Ingrid BK, Nadine C. Mitophagy in Yeast: Decades of Research. Cells. 2021 Dec 15;10(12). doi: 10.3390/cells10123541. PMID: 34944049; PMCID: PMC8700663.
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Cells. 2021 Dec 15;10(12). doi: 10.3390/cells10123541.

Mitophagy in Yeast: Decades of Research.

Cells

Bhatia-Kissova Ingrid, Camougrand Nadine

Affiliations

  1. Department of Biochemistry, Faculty of Natural Sciences, Comenius University, Ilkovi?ova 6, 84215 Bratislava, Slovakia.
  2. CNRS, UMR 5095, 1 Rue Camille Saint-Saëns, 33077 Bordeaux, France.
  3. Institut de Biochimie et de Génétique Cellulaires, Université de Bordeaux, UMR 5095, 1 Rue Camille Saint-Saëns, 33077 Bordeaux, France.

PMID: 34944049 PMCID: PMC8700663 DOI: 10.3390/cells10123541

Abstract

Mitophagy, the selective degradation of mitochondria by autophagy, is one of the most important mechanisms of mitochondrial quality control, and its proper functioning is essential for cellular homeostasis. In this review, we describe the most important milestones achieved during almost 2 decades of research on yeasts, which shed light on the molecular mechanisms, regulation, and role of the Atg32 receptor in this process. We analyze the role of ROS in mitophagy and discuss the physiological roles of mitophagy in unicellular organisms, such as yeast; these roles are very different from those in mammals. Additionally, we discuss some of the different tools available for studying mitophagy.

Keywords: Atg32 protein; mitochondria; mitophagy; quality control; yeast

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