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Smeriglio A, Denaro M, Di Gristina E, et al. Pharmacognostic approach to evaluate the micromorphological, phytochemical and biological features of Citrus lumia seeds. Food Chem. 2021;375:131855doi: 10.1016/j.foodchem.2021.131855.
Smeriglio, A., Denaro, M., Di Gristina, E., Mastracci, L., Grillo, F., Cornara, L., & Trombetta, D. (2021). Pharmacognostic approach to evaluate the micromorphological, phytochemical and biological features of Citrus lumia seeds. Food chemistry, 375131855. https://doi.org/10.1016/j.foodchem.2021.131855
Smeriglio, Antonella, et al. "Pharmacognostic approach to evaluate the micromorphological, phytochemical and biological features of Citrus lumia seeds." Food chemistry vol. 375 (2021): 131855. doi: https://doi.org/10.1016/j.foodchem.2021.131855
Smeriglio A, Denaro M, Di Gristina E, Mastracci L, Grillo F, Cornara L, Trombetta D. Pharmacognostic approach to evaluate the micromorphological, phytochemical and biological features of Citrus lumia seeds. Food Chem. 2021 Dec 14;375:131855. doi: 10.1016/j.foodchem.2021.131855. Epub 2021 Dec 14. PMID: 34953240.
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Food Chem. 2021 Dec 14;375:131855. doi: 10.1016/j.foodchem.2021.131855. Epub 2021 Dec 14.

Pharmacognostic approach to evaluate the micromorphological, phytochemical and biological features of Citrus lumia seeds.

Food chemistry

Antonella Smeriglio, Marcella Denaro, Emilio Di Gristina, Luca Mastracci, Federica Grillo, Laura Cornara, Domenico Trombetta

Affiliations

  1. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy. Electronic address: [email protected].
  2. Department of Chemical, Biological, Pharmaceutical and Environmental Sciences (ChiBioFarAm), University of Messina, Viale Ferdinando Stagno d'Alcontres 31, 98166 Messina, Italy.
  3. Department of Agricultural, Food and Forest Sciences (SAAF), University of Palermo, Viale delle Scienze, bldg. 4, 90128 Palermo, Italy.
  4. Department of Surgical and Diagnostic Sciences (DISC), Pathology Unit, University of Genova, Genova, Italy; Ospedale Policlinico San Martino, Largo Rosanna Benzi 10, 16125 Genova, Italy.
  5. Department of Surgical and Diagnostic Sciences (DISC), Pathology Unit, University of Genova, Genova, Italy.
  6. Department of Earth, Environment and Life Sciences (DISTAV), University of Genova, Corso Europa 26, 16132 Genova, Italy. Electronic address: [email protected].

PMID: 34953240 DOI: 10.1016/j.foodchem.2021.131855

Abstract

This study evaluated the micro-morphology as well as the chemical and biological features of Citrus lumia seeds. The cream-colored pyriform seed showed a woody coat covered by a thick layer of mucilage and an embryo with two large cotyledons rich in oil bodies. Hydroxycinnamic acid glycosides and flavonoids are the most abundant compounds in methanol and ethyl acetate extracts (ME and EAE), respectively. Conversely, fatty acids and α-tocopherol represent the main bioactive compounds in the hexane extract (HE). ME showed the most promising antioxidant and anti-inflammatory activities already in cell-free assays. These results were confirmed by experiments carried out on human primary cells. Indeed, ME showed the best inhibitory activity against heat-induced haemolysis and ROS formation in erythrocytes. Moreover, the same order of potency (ME > EAE > HE) was observed also on peripheral blood mononuclear cells, in which the seed extracts were able to decrease TNF-α and IL-6 release after LPS-induced inflammation.

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Anti-inflammatory activity; Antioxidant properties; Citrus lumia Risso; Micro-morphological features; Phytochemical profile; Seed extract

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