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Tchetina EV, Satybaldyev AM, Markova GA, et al. Putative Association between Low Baseline Gene Expression in the Peripheral Blood and Clinical Remission in Rheumatoid Arthritis Patients Treated with Tofacitinib. Life (Basel). 2021;11(12)doi: 10.3390/life11121385.
Tchetina, E. V., Satybaldyev, A. M., Markova, G. A., Samarkina, E. Y., & Lila, A. M. (2021). Putative Association between Low Baseline Gene Expression in the Peripheral Blood and Clinical Remission in Rheumatoid Arthritis Patients Treated with Tofacitinib. Life (Basel, Switzerland), 11(12), . https://doi.org/10.3390/life11121385
Tchetina, Elena V, et al. "Putative Association between Low Baseline Gene Expression in the Peripheral Blood and Clinical Remission in Rheumatoid Arthritis Patients Treated with Tofacitinib." Life (Basel, Switzerland) vol. 11,12 (2021). doi: https://doi.org/10.3390/life11121385
Tchetina EV, Satybaldyev AM, Markova GA, Samarkina EY, Lila AM. Putative Association between Low Baseline Gene Expression in the Peripheral Blood and Clinical Remission in Rheumatoid Arthritis Patients Treated with Tofacitinib. Life (Basel). 2021 Dec 11;11(12). doi: 10.3390/life11121385. PMID: 34947916; PMCID: PMC8705250.
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Life (Basel). 2021 Dec 11;11(12). doi: 10.3390/life11121385.

Putative Association between Low Baseline Gene Expression in the Peripheral Blood and Clinical Remission in Rheumatoid Arthritis Patients Treated with Tofacitinib.

Life (Basel, Switzerland)

Elena V Tchetina, Azamat M Satybaldyev, Galina A Markova, Elena Yu Samarkina, Aleksandr M Lila

Affiliations

  1. Immunology and Molecular Biology Laboratory, Nasonova Research Institute of Rheumatology, 115522 Moscow, Russia.
  2. Early Rheumatoid Arthritis Department, Nasonova Research Institute of Rheumatology, 115522 Moscow, Russia.

PMID: 34947916 PMCID: PMC8705250 DOI: 10.3390/life11121385

Abstract

We investigated the importance of the baseline expression of genes involved in energy generation, as prognostic biomarkers of the treatment response to tofacitinib in patients with rheumatoid arthritis (RA). Peripheral blood samples were obtained from 28 patients with RA who received 3 months of tofacitinib therapy from 26 healthy controls. Clinical response was evaluated based on the disease activity score, the erythrocyte sedimentation rate (DAS28-ESR), and the serum levels of ACPA, RF, CRP, and ESR. Clinical remission was assessed based on DAS28 score <2.6. Protein concentrations were measured using ELISA. Total RNA isolated from whole blood was used for gene expression analysis using quantitative RT-PCR. All patients were diagnosed with Steinbrocker's radiographic stage II-III at baseline, and most showed erosive arthritis with ACPA and RF positivity. Tofacitinib treatment significantly decreased the disease activity. Upon study completion, seven patients showed remission. Before and after TOFA therapy, a significantly higher expression of succinate dehydrogenase and pyruvate kinase genes was observed in all the examined patients compared to healthy subjects. However, the pre-therapy expression of these genes and corresponding proteins was significantly (

Keywords: gene expression; remission; rheumatoid arthritis; tofacitinib; whole blood

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