Display options
Cite
Carobeli LR, Meirelles LEF, Damke GMZF, et al. Phthalocyanine and Its Formulations: A Promising Photosensitizer for Cervical Cancer Phototherapy. Pharmaceutics. 2021;13(12)doi: 10.3390/pharmaceutics13122057.
Carobeli, L. R., Meirelles, L. E. F., Damke, G. M. Z. F., Damke, E., Souza, M. V. F., Mari, N. L., Mashiba, K. H., Shinobu-Mesquita, C. S., Souza, R. P., Silva, V. R. S. D., Gonçalves, R. S., Caetano, W., & Consolaro, M. E. L. (2021). Phthalocyanine and Its Formulations: A Promising Photosensitizer for Cervical Cancer Phototherapy. Pharmaceutics, 13(12), . https://doi.org/10.3390/pharmaceutics13122057
Carobeli, Lucimara R, et al. "Phthalocyanine and Its Formulations: A Promising Photosensitizer for Cervical Cancer Phototherapy." Pharmaceutics vol. 13,12 (2021). doi: https://doi.org/10.3390/pharmaceutics13122057
Carobeli LR, Meirelles LEF, Damke GMZF, Damke E, Souza MVF, Mari NL, Mashiba KH, Shinobu-Mesquita CS, Souza RP, Silva VRSD, Gonçalves RS, Caetano W, Consolaro MEL. Phthalocyanine and Its Formulations: A Promising Photosensitizer for Cervical Cancer Phototherapy. Pharmaceutics. 2021 Dec 02;13(12). doi: 10.3390/pharmaceutics13122057. PMID: 34959339; PMCID: PMC8705941.
Copy Download .nbib Format: NLM
Share it on

Pharmaceutics. 2021 Dec 02;13(12). doi: 10.3390/pharmaceutics13122057.

Phthalocyanine and Its Formulations: A Promising Photosensitizer for Cervical Cancer Phototherapy.

Pharmaceutics

Lucimara R Carobeli, Lyvia E de F Meirelles, Gabrielle M Z F Damke, Edilson Damke, Maria V F de Souza, Natália L Mari, Kayane H Mashiba, Cristiane S Shinobu-Mesquita, Raquel P Souza, Vânia R S da Silva, Renato S Gonçalves, Wilker Caetano, Márcia E L Consolaro

Affiliations

  1. Department of Clinical Analysis and Biomedicine, Universidade Estadual de Maringá, Maringá 87020-900, PR, Brazil.
  2. Department of Chemistry, Universidade Estadual de Maringá, Maringá 87020-900, PR, Brazil.

PMID: 34959339 PMCID: PMC8705941 DOI: 10.3390/pharmaceutics13122057

Abstract

Cervical cancer is one of the most common causes of cancer-related deaths in women worldwide. Despite advances in current therapies, women with advanced or recurrent disease present poor prognosis. Photodynamic therapy (PDT) has emerged as an effective therapeutic alternative to treat oncological diseases such as cervical cancer. Phthalocyanines (Pcs) are considered good photosensitizers (PS) for PDT, although most of them present high levels of aggregation and are lipophilic. Despite many investigations and encouraging results, Pcs have not been approved as PS for PDT of invasive cervical cancer yet. This review presents an overview on the pathophysiology of cervical cancer and summarizes the most recent developments on the physicochemical properties of Pcs and biological results obtained both in vitro in tumor-bearing mice and in clinical tests reported in the last five years. Current evidence indicates that Pcs have potential as pharmaceutical agents for anti-cervical cancer therapy. The authors firmly believe that Pc-based formulations could emerge as a privileged scaffold for the establishment of lead compounds for PDT against different types of cervical cancer.

Keywords: in vitro; in vivo; photochemotherapy; phthalocyanine; uterine cervical neoplasms

References

  1. J Med Chem. 2018 Aug 23;61(16):7189-7201 - PubMed
  2. Nat Rev Cancer. 2010 Apr;10(4):241-53 - PubMed
  3. J Virol. 1997 Jul;71(7):5161-72 - PubMed
  4. Free Radic Biol Med. 2011 Aug 15;51(4):824-33 - PubMed
  5. Biomed Opt Express. 2020 Jun 22;11(7):3900-3912 - PubMed
  6. Invest New Drugs. 2021 Feb;39(1):89-97 - PubMed
  7. Pharmaceutics. 2020 Jun 30;12(7): - PubMed
  8. Photochem Photobiol. 1993 Aug;58(2):204-10 - PubMed
  9. Drug Discov Today. 2017 Aug;22(8):1274-1283 - PubMed
  10. J Clin Oncol. 2018 Jun 1;36(16):1548-1555 - PubMed
  11. J Virol. 1995 Jun;69(6):3381-8 - PubMed
  12. Photochem Photobiol. 2015 Jul-Aug;91(4):931-6 - PubMed
  13. Am J Cancer Res. 2016 Nov 01;6(11):2690-2699 - PubMed
  14. Oncotarget. 2017 Aug 11;8(46):81591-81603 - PubMed
  15. J Photochem Photobiol B. 2021 Feb;215:112122 - PubMed
  16. Chem Rev. 2015 Feb 25;115(4):1990-2042 - PubMed
  17. Int J Gynecol Cancer. 2020 Jun;30(6):873-878 - PubMed
  18. J Photochem Photobiol B. 2019 Jan;190:1-7 - PubMed
  19. Autophagy. 2010 Jan;6(1):7-18 - PubMed
  20. Trends Biotechnol. 1995 Jan;13(1):14-8 - PubMed
  21. J Eur Acad Dermatol Venereol. 2001 Nov;15(6):508-9 - PubMed
  22. J Control Release. 2018 Aug 28;284:1-14 - PubMed
  23. Photochem Photobiol Sci. 2015 Aug;14(8):1476-91 - PubMed
  24. Cell. 1993 Nov 5;75(3):495-505 - PubMed
  25. Sci Rep. 2017 Jul 27;7(1):6734 - PubMed
  26. Photochem Photobiol. 1992 Jul;56(1):43-50 - PubMed
  27. J Oral Pathol Med. 2014 Oct;43(9):675-84 - PubMed
  28. Adv Mater. 2018 Nov;30(45):e1801350 - PubMed
  29. Cancers (Basel). 2011 Mar 03;3(1):1014-41 - PubMed
  30. J Natl Cancer Inst. 1998 Jun 17;90(12):889-905 - PubMed
  31. Photochem Photobiol. 1995 Sep;62(3):542-5 - PubMed
  32. Sci Rep. 2019 Feb 13;9(1):1913 - PubMed
  33. Br J Cancer. 1999 Jul;80(10):1533-41 - PubMed
  34. Viruses. 2017 Sep 19;9(9): - PubMed
  35. Med Laser Appl. 2006 Nov 15;21(4):219-224 - PubMed
  36. Photochem Photobiol. 1986 Jun;43(6):691-9 - PubMed
  37. Photodiagnosis Photodyn Ther. 2012 Jun;9(2):122-31 - PubMed
  38. Int J Gynaecol Obstet. 2008 Dec;103(3):232-6 - PubMed
  39. Pharm Res. 2018 Feb 08;35(3):57 - PubMed
  40. Cancers (Basel). 2017 Feb 18;9(2): - PubMed
  41. Toxicol Appl Pharmacol. 2007 Nov 1;224(3):290-9 - PubMed
  42. J Photochem Photobiol B. 1997 May;39(1):1-18 - PubMed
  43. Biotechniques. 2009 Apr;46(4):277-84 - PubMed
  44. Chem Rev. 1999 Sep 8;99(9):2379-450 - PubMed
  45. ACS Med Chem Lett. 2021 Mar 01;12(3):502-507 - PubMed
  46. J Exp Med. 1953 May;97(5):695-710 - PubMed
  47. J Photochem Photobiol B. 1990 Mar;4(4):379-90 - PubMed
  48. Int J Cancer. 2017 Jan 15;140(2):440-448 - PubMed
  49. Anticancer Res. 2019 Jul;39(7):3323-3339 - PubMed
  50. J Pharm Sci. 1994 Apr;83(4):601-6 - PubMed
  51. Chem Soc Rev. 2016 Nov 21;45(23):6488-6519 - PubMed
  52. Radiat Oncol. 2018 Dec 17;13(1):249 - PubMed
  53. Expert Opin Drug Discov. 2018 May;13(5):445-457 - PubMed
  54. Photodiagnosis Photodyn Ther. 2020 Dec;32:102004 - PubMed
  55. Viruses. 2015 Jul 16;7(7):3863-90 - PubMed
  56. Microbes Infect. 2006 Aug;8(9-10):2517-21 - PubMed
  57. Photodiagnosis Photodyn Ther. 2016 Dec;16:100-105 - PubMed
  58. Nat Rev Cancer. 2006 Jul;6(7):535-45 - PubMed
  59. Photochem Photobiol. 1996 May;63(5):656-61 - PubMed
  60. EMBO J. 2005 May 18;24(10):1821-30 - PubMed
  61. J Dermatolog Treat. 2002;13 Suppl 1:S3-11 - PubMed
  62. CA Cancer J Clin. 2021 May;71(3):209-249 - PubMed
  63. Int J Mol Sci. 2015 Aug 31;16(9):20523-59 - PubMed
  64. Gynecol Oncol. 2015 Apr;137(1):47-54 - PubMed
  65. J Virol. 1991 May;65(5):2254-60 - PubMed
  66. Methods Enzymol. 2000;319:342-58 - PubMed
  67. Colloids Surf B Biointerfaces. 2018 Feb 1;162:76-89 - PubMed
  68. EMBO J. 1989 Dec 20;8(13):4099-105 - PubMed
  69. Chem Soc Rev. 2020 Feb 21;49(4):1041-1056 - PubMed
  70. J Am Acad Dermatol. 2000 Mar;42(3):389-413; quiz 414-6 - PubMed
  71. PLoS Pathog. 2009 Feb;5(2):e1000318 - PubMed
  72. Org Biomol Chem. 2021 Feb 18;19(6):1168-1190 - PubMed
  73. EMBO J. 1991 Dec;10(13):4129-35 - PubMed
  74. Virus Res. 2002 Nov;89(2):249-61 - PubMed
  75. Int J Pharm. 2016 May 30;505(1-2):369-75 - PubMed
  76. J Healthc Eng. 2013;4(1):87-108 - PubMed
  77. Chempluschem. 2019 Jun;84(6):673-679 - PubMed
  78. Angew Chem Int Ed Engl. 2007;46(44):8358-62 - PubMed
  79. J Photochem Photobiol B. 2006 Apr 3;83(1):55-62 - PubMed
  80. J Med Chem. 2000 Jun 15;43(12):2403-10 - PubMed
  81. Cancer Lett. 1997 Feb 26;113(1-2):25-9 - PubMed
  82. Molecules. 2016 Mar 11;21(3):342 - PubMed
  83. Int J Gynaecol Obstet. 2017 Jul;138 Suppl 1:20-25 - PubMed
  84. J Natl Cancer Inst. 2006 Mar 1;98(5):303-15 - PubMed
  85. N Engl J Med. 1998 Feb 12;338(7):423-8 - PubMed
  86. Biophys Chem. 2019 Oct;253:106228 - PubMed
  87. Cancer Biol Med. 2012 Mar;9(1):9-17 - PubMed
  88. Lancet Oncol. 2010 Nov;11(11):1048-56 - PubMed
  89. J Photochem Photobiol B. 1998 Aug 21;45(1):28-35 - PubMed
  90. Photodiagnosis Photodyn Ther. 2004 May;1(1):27-42 - PubMed
  91. Biochim Biophys Acta. 2007 Sep;1776(1):86-107 - PubMed
  92. Eur J Cancer. 2012 Sep;48(13):2086-96 - PubMed
  93. Lancet. 2019 Jan 12;393(10167):169-182 - PubMed
  94. J Photochem Photobiol B. 2002 Mar;66(2):89-106 - PubMed
  95. Pathogens. 2020 Jun 18;9(6): - PubMed
  96. Chem Biol Interact. 2009 May 15;179(2-3):402-6 - PubMed
  97. Int J Hyperthermia. 2020 Dec;37(3):50-58 - PubMed
  98. Biochem J. 2016 Feb 15;473(4):347-64 - PubMed
  99. Am J Ophthalmol. 2016 Jan;161:104-9.e1-2 - PubMed
  100. Sex Transm Infect. 2011 Aug;87(5):372-6 - PubMed
  101. Chem Biol Drug Des. 2018 Mar;91(3):789-796 - PubMed
  102. Lancet. 2017 Nov 11;390(10108):2143-2159 - PubMed
  103. Infect Agent Cancer. 2020 May 13;15:33 - PubMed
  104. Photochem Photobiol. 2018 Mar;94(2):213-218 - PubMed
  105. J Photochem Photobiol B. 2004 Jan 23;73(1-2):1-28 - PubMed
  106. Science. 1989 Feb 17;243(4893):934-7 - PubMed
  107. Bioorg Med Chem. 2007 Jul 15;15(14):4829-35 - PubMed
  108. Braz J Med Biol Res. 2007 Aug;40(8):1025-35 - PubMed
  109. Br J Obstet Gynaecol. 1999 Dec;106(12):1246-54 - PubMed
  110. EMBO J. 1984 May;3(5):1151-7 - PubMed
  111. Nat Cell Biol. 2014 Aug;16(8):728-36 - PubMed
  112. J Med Chem. 2021 Feb 25;64(4):2064-2076 - PubMed
  113. J Virol. 1992 Oct;66(10):6070-80 - PubMed
  114. Autophagy. 2011 Sep;7(9):979-84 - PubMed
  115. Med Sci Monit Basic Res. 2016 Dec 9;22:156-164 - PubMed
  116. Cell. 1990 Dec 21;63(6):1129-36 - PubMed
  117. ACS Nano. 2019 Jun 25;13(6):6702-6710 - PubMed
  118. Lasers Surg Med. 2013 Mar;45(3):186-94 - PubMed
  119. Lasers Surg Med. 2011 Sep;43(7):755-67 - PubMed
  120. J Med Chem. 2020 Jul 23;63(14):7616-7632 - PubMed
  121. J Physiol Pharmacol. 2012 Apr;63(2):109-18 - PubMed
  122. Am J Cancer Res. 2016 Jun 01;6(6):1371-83 - PubMed
  123. Prev Med. 2011 Oct;53 Suppl 1:S12-21 - PubMed
  124. Bioorg Med Chem. 2017 Mar 1;25(5):1643-1651 - PubMed
  125. Cancer Res. 1991 Nov 1;51(21):5993-6 - PubMed
  126. J Virol. 1998 Apr;72(4):2715-22 - PubMed
  127. Eur J Gynaecol Oncol. 2003;24(6):513-6 - PubMed
  128. Expert Rev Anticancer Ther. 2017 Aug;17(8):693-702 - PubMed
  129. Photodiagnosis Photodyn Ther. 2016 Dec;16:124-131 - PubMed
  130. Virology. 1985 Sep;145(2):313-8 - PubMed
  131. Photochem Photobiol Sci. 2019 Nov 1;18(11):2792-2803 - PubMed
  132. Virology. 2009 Feb 20;384(2):324-34 - PubMed
  133. Mol Pharm. 2020 Jan 6;17(1):190-201 - PubMed
  134. Molecules. 2020 Jan 04;25(1): - PubMed
  135. Front Chem. 2021 Jun 10;9:691697 - PubMed
  136. Bioorg Med Chem. 2016 Sep 15;24(18):4152-4164 - PubMed
  137. Mol Cancer Ther. 2006 Mar;5(3):776-85 - PubMed
  138. Lasers Surg Med. 2006 Jun;38(5):489-93 - PubMed
  139. CA Cancer J Clin. 2011 Jul-Aug;61(4):250-81 - PubMed
  140. Acc Chem Res. 2009 Dec 21;42(12):1910-21 - PubMed
  141. Photodermatol Photoimmunol Photomed. 2010 Jun;26(3):118-32 - PubMed
  142. Photodiagnosis Photodyn Ther. 2012 Mar;9(1):52-9 - PubMed
  143. Int J Gynecol Cancer. 2015 Oct;25(8):1345-52 - PubMed
  144. Virology. 1999 Apr 25;257(1):239-46 - PubMed
  145. Drug Discov Today. 1999 Nov;4(11):507-517 - PubMed
  146. Expert Opin Emerg Drugs. 2015 Jun;20(2):165-82 - PubMed
  147. Biochim Biophys Acta. 2010 Jan;1805(1):53-71 - PubMed
  148. Photodiagnosis Photodyn Ther. 2014 Jun;11(2):104-12 - PubMed
  149. J Natl Cancer Inst. 1975 Jul;55(1):115-21 - PubMed
  150. Nanoscale. 2019 Feb 14;11(7):3386-3395 - PubMed
  151. Carbohydr Polym. 2016 Sep 5;148:236-42 - PubMed
  152. Dalton Trans. 2021 Feb 21;50(7):2570-2584 - PubMed
  153. Am J Obstet Gynecol. 2015 Apr;212(4):465.e1-7 - PubMed
  154. An Bras Dermatol. 2010 Jul-Aug;85(4):501-11 - PubMed
  155. J Pathol. 1999 Sep;189(1):12-9 - PubMed
  156. Br J Cancer. 1987 Nov;56(5):597-600 - PubMed
  157. Br J Cancer. 1998 Mar;77(6):965-72 - PubMed
  158. Angew Chem Int Ed Engl. 2008;47(22):4173-6 - PubMed
  159. Nat Rev Dis Primers. 2016 Dec 01;2:16086 - PubMed
  160. Theranostics. 2021 Jan 15;11(7):3278-3300 - PubMed
  161. Dalton Trans. 2016 Mar 7;45(9):3853-62 - PubMed
  162. Photochem Photobiol. 1985 Nov;42(5):515-21 - PubMed
  163. Int J Cancer. 2010 Jul 1;127(1):1-8 - PubMed
  164. Lasers Surg Med. 2010 Oct;42(8):728-35 - PubMed
  165. Lancet. 2019 Mar 9;393(10175):969-970 - PubMed
  166. Trends Microbiol. 2011 Jan;19(1):33-9 - PubMed
  167. J Photochem Photobiol B. 2017 Dec;177:32-38 - PubMed
  168. J Eur Acad Dermatol Venereol. 2007 Mar;21(3):293-302 - PubMed
  169. Nature. 1985 Mar 7-13;314(6006):111-4 - PubMed
  170. J Natl Compr Canc Netw. 2015 Apr;13(4):395-404; quiz 404 - PubMed
  171. Clin Cancer Res. 2000 May;6(5):2021-7 - PubMed
  172. Adv Biol Chem. 2016 Dec;6(6):193-215 - PubMed
  173. Cancers (Basel). 2011;3(2):2516-39 - PubMed

Publication Types

Grant support