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Radocchia G, Neroni B, Marazzato M, et al. Chronic Intestinal Pseudo-Obstruction: Is There a Connection with Gut Microbiota?. Microorganisms. 2021;9(12)doi: 10.3390/microorganisms9122549.
Radocchia, G., Neroni, B., Marazzato, M., Capuzzo, E., Zuccari, S., Pantanella, F., Zenzeri, L., Evangelisti, M., Vassallo, F., Parisi, P., Di Nardo, G., & Schippa, S. (2021). Chronic Intestinal Pseudo-Obstruction: Is There a Connection with Gut Microbiota?. Microorganisms, 9(12), . https://doi.org/10.3390/microorganisms9122549
Radocchia, Giulia, et al. "Chronic Intestinal Pseudo-Obstruction: Is There a Connection with Gut Microbiota?." Microorganisms vol. 9,12 (2021). doi: https://doi.org/10.3390/microorganisms9122549
Radocchia G, Neroni B, Marazzato M, Capuzzo E, Zuccari S, Pantanella F, Zenzeri L, Evangelisti M, Vassallo F, Parisi P, Di Nardo G, Schippa S. Chronic Intestinal Pseudo-Obstruction: Is There a Connection with Gut Microbiota?. Microorganisms. 2021 Dec 10;9(12). doi: 10.3390/microorganisms9122549. PMID: 34946150.
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Microorganisms. 2021 Dec 10;9(12). doi: 10.3390/microorganisms9122549.

Chronic Intestinal Pseudo-Obstruction: Is There a Connection with Gut Microbiota?.

Microorganisms

Giulia Radocchia, Bruna Neroni, Massimiliano Marazzato, Elena Capuzzo, Simone Zuccari, Fabrizio Pantanella, Letizia Zenzeri, Melania Evangelisti, Francesca Vassallo, Pasquale Parisi, Giovanni Di Nardo, Serena Schippa

Affiliations

  1. Department of Public Health and Infection Disease, Microbiology Section, Sapienza University of Rome, 00185 Rome, Italy.
  2. Paediatric Unit, NESMOS Department, Faculty of Medicine and Psychology, Sant'Andrea University Hospital, Sapienza University of Rome, 00185 Rome, Italy.
  3. Paediatric Emergency Department, Santobono-Pausilipon Children's Hospital, 80129 Naples, Italy.

PMID: 34946150 DOI: 10.3390/microorganisms9122549

Abstract

Chronic intestinal pseudo-obstruction (CIPO) is a rare clinical syndrome characterized by severe impairment of gastrointestinal (GI) motility, and its symptoms are suggestive of partial or complete intestinal obstruction in the absence of any lesion restricting the intestinal lumen. Diagnosis and therapy of CIPO patients still represent a significant challenge for clinicians, despite their efforts to improve diagnostic workup and treatment strategies for this disease. The purpose of this review is to better understand what is currently known about the relationship between CIPO patients and intestinal microbiota, with a focus on the role of the enteric nervous system (ENS) and the intestinal endocrine system (IES) in intestinal motility, underling the importance of further studies to deeply understand the causes of gut motility dysfunction in these patients.

Keywords: chronic intestinal pseudo-obstruction; gut microbiota; intestinal motility; neurotransmitters

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