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de Mello VD, Selander T, Lindström J, et al. Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study. Nutrients. 2021;13(12)doi: 10.3390/nu13124452.
de Mello, V. D., Selander, T., Lindström, J., Tuomilehto, J., Uusitupa, M., & Kaarniranta, K. (2021). Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study. Nutrients, 13(12), . https://doi.org/10.3390/nu13124452
de Mello, Vanessa Derenji, et al. "Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study." Nutrients vol. 13,12 (2021). doi: https://doi.org/10.3390/nu13124452
de Mello VD, Selander T, Lindström J, Tuomilehto J, Uusitupa M, Kaarniranta K. Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study. Nutrients. 2021 Dec 14;13(12). doi: 10.3390/nu13124452. PMID: 34960007; PMCID: PMC8703764.
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Nutrients. 2021 Dec 14;13(12). doi: 10.3390/nu13124452.

Serum Levels of Plasmalogens and Fatty Acid Metabolites Associate with Retinal Microangiopathy in Participants from the Finnish Diabetes Prevention Study.

Nutrients

Vanessa Derenji de Mello, Tuomas Selander, Jaana Lindström, Jaakko Tuomilehto, Matti Uusitupa, Kai Kaarniranta

Affiliations

  1. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, FI-70211 Kuopio, Finland.
  2. Science Service Center, Kuopio University Hospital, FI-70029 Kuopio, Finland.
  3. Public Health Prevention Unit, Finnish Institute for Health and Welfare, FI-00271 Helsinki, Finland.
  4. Department of Public Health, University of Helsinki, FI-00014 Helsinki, Finland.
  5. Diabetes Research Group, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
  6. Department of Ophthalmology, Kuopio University Hospital, FI-70029 Kuopio, Finland.
  7. Institute of Clinical Medicine, Faculty of Health Sciences, University of Eastern Finland, FI-70211 Kuopio, Finland.

PMID: 34960007 PMCID: PMC8703764 DOI: 10.3390/nu13124452

Abstract

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes, and retinal microaneurysms (MA) are one of the first detected abnormalities associated with DR. We recently showed elevated serum triglyceride levels to be associated with the development of MA in the Finnish Diabetes Prevention Study (DPS). The purpose of this metabolomics study was to assess whether serum fatty acid (FA) composition, plasmalogens, and low-grade inflammation may enhance or decrease the risk of MA. Originally, the DPS included 522 individuals (mean 55 years old, range 40-64 years) with impaired glucose tolerance who were randomized into an intervention (

Keywords: diabetic nephropathy; lifestyles; plasmalogens; serum fatty acids

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