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Corrà F, Crudele F, Baldassari F, et al. UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. Genes (Basel). 2021;12(12)doi: 10.3390/genes12121978.
Corrà, F., Crudele, F., Baldassari, F., Bianchi, N., Galasso, M., Minotti, L., Agnoletto, C., Di Leva, G., Brugnoli, F., Reali, E., Bertagnolo, V., Vecchione, A., & Volinia, S. (2021). UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. Genes, 12(12), . https://doi.org/10.3390/genes12121978
Corrà, Fabio, et al. "UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines." Genes vol. 12,12 (2021). doi: https://doi.org/10.3390/genes12121978
Corrà F, Crudele F, Baldassari F, Bianchi N, Galasso M, Minotti L, Agnoletto C, Di Leva G, Brugnoli F, Reali E, Bertagnolo V, Vecchione A, Volinia S. UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines. Genes (Basel). 2021 Dec 13;12(12). doi: 10.3390/genes12121978. PMID: 34946928.
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Genes (Basel). 2021 Dec 13;12(12). doi: 10.3390/genes12121978.

UC.183, UC.110, and UC.84 Ultra-Conserved RNAs Are Mutually Exclusive with miR-221 and Are Engaged in the Cell Cycle Circuitry in Breast Cancer Cell Lines.

Genes

Fabio Corrà, Francesca Crudele, Federica Baldassari, Nicoletta Bianchi, Marco Galasso, Linda Minotti, Chiara Agnoletto, Gianpiero Di Leva, Federica Brugnoli, Eva Reali, Valeria Bertagnolo, Andrea Vecchione, Stefano Volinia

Affiliations

  1. Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA), Department of Translational Medicine, University of Ferrara, Via Fossato di Mortara 70, 44121 Ferrara, Italy.
  2. Advanced Translational Research Laboratory, Veneto Institute of Oncology IOV-IRCCS, 35127 Padua, Italy.
  3. School of Pharmacy and Bioengineering, Guy Hilton Research Centre, Keele University, Stoke-on-Trent ST4 7QB, UK.
  4. Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126 Milan, Italy.
  5. Department of Medical Surgical Science and Translational Medicine-c/o Azienda Ospedaliera Sant'Andrea, Via di Grottarossa 1035, 00189 Rome, Italy.

PMID: 34946928 DOI: 10.3390/genes12121978

Abstract

In the human genome, there are about 600 ultra-conserved regions (UCRs), long DNA sequences extremely conserved in vertebrates. We performed a large-scale study to quantify transcribed UCR (T-UCR) and miRNA levels in over 6000 cancer and normal tissue samples to find possible correlation between these kinds of regulatory molecules. Our analysis evidenced several non-coding RNAs showing negative co-regulation with miRNAs; among them, we focused on miR-221 to investigate any relationship with its pivotal role in the cell cycle. We have chosen breast cancer as model, using two cell lines with different phenotypes to carry out in vitro treatments with siRNAs against T-UCRs. Our results demonstrate that the expression of uc.183, uc.110, and uc.84 T-UCRs is mutually exclusive with miR-221 and is engaged in the regulation of

Keywords: MIR221; UCR; alpelisib; breast cancer; capivasertib; cell cycle; voxtalisib

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