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Lima TC, Magalhães LG, Paula LAL, et al. Evaluation of lignan-loaded poly(ε-caprolactone) nanoparticles: synthesis, characterization, . Nat Prod Res. 2021;1-7doi: 10.1080/14786419.2021.2021515.
Lima, T. C., Magalhães, L. G., Paula, L. A. L., Cunha, W. R., Januário, A. H., Pauletti, P. M., Bastos, J. K., Dos Santos, F. F., Forim, M. R., Laurentiz, R. S., Santos, F. A., Orenha, R. P., Parreira, R. L. T., Fuzo, C. A., Molina, E. F., Santos, M. F. C., & Silva, M. L. A. E. (2021). Evaluation of lignan-loaded poly(ε-caprolactone) nanoparticles: synthesis, characterization, . Natural product research, 1-7. https://doi.org/10.1080/14786419.2021.2021515
Lima, Thais C, et al. "Evaluation of lignan-loaded poly(ε-caprolactone) nanoparticles: synthesis, characterization, ." Natural product research vol. (2021): 1-7. doi: https://doi.org/10.1080/14786419.2021.2021515
Lima TC, Magalhães LG, Paula LAL, Cunha WR, Januário AH, Pauletti PM, Bastos JK, Dos Santos FF, Forim MR, Laurentiz RS, Santos FA, Orenha RP, Parreira RLT, Fuzo CA, Molina EF, Santos MFC, Silva MLAE. Evaluation of lignan-loaded poly(ε-caprolactone) nanoparticles: synthesis, characterization, . Nat Prod Res. 2021 Dec 29;1-7. doi: 10.1080/14786419.2021.2021515. Epub 2021 Dec 29. PMID: 34963393.
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Nat Prod Res. 2021 Dec 29;1-7. doi: 10.1080/14786419.2021.2021515. Epub 2021 Dec 29.

Evaluation of lignan-loaded poly(ε-caprolactone) nanoparticles: synthesis, characterization, .

Natural product research

Thais C Lima, Lizandra G Magalhães, Lucas A de L Paula, Wilson R Cunha, Ana H Januário, Patricia M Pauletti, Jairo K Bastos, Fransergio F Dos Santos, Moacir R Forim, Rosangela S Laurentiz, Fernanda A Santos, Renato P Orenha, Renato L T Parreira, Carlos A Fuzo, Eduardo F Molina, Mario F C Santos, Márcio L A E Silva

Affiliations

  1. Universidade de Franca, Franca, São Paulo, Brazil.
  2. School of Pharmaceutical Sciences of Ribeirão Preto - USP, Ribeirão Preto, São Paulo, Brazil.
  3. Instituto de Química de São Carlos, São Carlos, São Paulo, Brazil.
  4. Departamento de Física e Química, Faculdade de Engenharia de Ilha Solteira, Universidade Estadual Paulista, Ilha Solteira, São Paulo, Brazil.

PMID: 34963393 DOI: 10.1080/14786419.2021.2021515

Abstract

Lignan dinitrohinokinin displays important biological activities, which led to the preparation of its poly-ε-caprolactone nanoparticles. Kinetics analysis revealed initially slow drug release followed by a prolonged, moderate release 6 h later due to DNHK diffusion through the polymeric matrix. Molecular dynamics simulations show that DNHK molecules that interact stronger with other DNHK molecules near the PCL/DNHK surface are more difficult to dissociate from the nanoparticle. The smaller diameter nanocapsules with negative surface charge conferred good colloidal stability. The formulations showed a size distribution with monodisperse systems formation.

Keywords: (−)-6,6’-dinitrohinokinin (DNHK); anti-inflammatory activity; polymeric nanoparticles; schistosomicidal activity

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