Display options
Cite
Tseilikman V, Komelkova M, Kondashevskaya MV, et al. A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland. Int J Mol Sci. 2021;22(24)doi: 10.3390/ijms222413235.
Tseilikman, V., Komelkova, M., Kondashevskaya, M. V., Manukhina, E., Downey, H. F., Chereshnev, V., Chereshneva, M., Platkovskii, P., Goryacheva, A., Pashkov, A., Fedotova, J., Tseilikman, O., Maltseva, N., Cherkasova, O., Steenblock, C., Bornstein, S. R., Ettrich, B., Chrousos, G. P., & Ullmann, E. (2021). A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland. International journal of molecular sciences, 22(24), . https://doi.org/10.3390/ijms222413235
Tseilikman, Vadim, et al. "A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland." International journal of molecular sciences vol. 22,24 (2021). doi: https://doi.org/10.3390/ijms222413235
Tseilikman V, Komelkova M, Kondashevskaya MV, Manukhina E, Downey HF, Chereshnev V, Chereshneva M, Platkovskii P, Goryacheva A, Pashkov A, Fedotova J, Tseilikman O, Maltseva N, Cherkasova O, Steenblock C, Bornstein SR, Ettrich B, Chrousos GP, Ullmann E. A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland. Int J Mol Sci. 2021 Dec 08;22(24). doi: 10.3390/ijms222413235. PMID: 34948031.
Copy Download .nbib Format: NLM
Share it on

Int J Mol Sci. 2021 Dec 08;22(24). doi: 10.3390/ijms222413235.

A Rat Model of Post-Traumatic Stress Syndrome Causes Phenotype-Associated Morphological Changes and Hypofunction of the Adrenal Gland.

International journal of molecular sciences

Vadim Tseilikman, Maria Komelkova, Marina V Kondashevskaya, Eugenia Manukhina, H Fred Downey, Valerii Chereshnev, Margarita Chereshneva, Pavel Platkovskii, Anna Goryacheva, Anton Pashkov, Julia Fedotova, Olga Tseilikman, Natalya Maltseva, Olga Cherkasova, Charlotte Steenblock, Stefan R Bornstein, Barbara Ettrich, George P Chrousos, Enrico Ullmann

Affiliations

  1. School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
  2. Institute of Immunology and Physiology, Ural Branch of the Russian Academy of Science, 620049 Ekaterinburg, Russia.
  3. Faculty of Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia.
  4. Laboratory for Immunomorphology of Inflammation, Research Institute of Human Morphology, 117418 Moscow, Russia.
  5. Laboratory for Regulatory Mechanisms of Stress and Adaptation, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russia.
  6. Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX 76107, USA.
  7. Laboratory of Neuroendocrinology, I.P. Pavlov Institute of Physiology RAS, 6 Emb. Makarova, 199034 Saint Petersburg, Russia.
  8. International Research Centre "Biotechnologies of the Third Millennium", ITMO University, 191002 Saint Petersburg, Russia.
  9. Biophysics Laboratory, Institute of Laser Physics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.
  10. Department of Medicine, Technical University of Dresden, 01309 Dresden, Germany.
  11. Rayne Institute, Division of Diabetes & Nutritional Sciences, Endocrinology and Diabetes, Faculty of Life Sciences & Medicine, Kings College London, London SE5 9PJ, UK.
  12. Department of Psychiatry and Psychotherapy, University of Leipzig, 04107 Leipzig, Germany.
  13. University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  14. Department of Child and Adolescent Psychiatry, Psychotherapy, and Psychosomatics, University of Leipzig, 04107 Leipzig, Germany.

PMID: 34948031 DOI: 10.3390/ijms222413235

Abstract

BACKGROUND: Rats exposed to chronic predator scent stress mimic the phenotype of complex post-traumatic stress disorder (PTSD) in humans, including altered adrenal morphology and function. High- and low-anxiety phenotypes have been described in rats exposed to predator scent stress (PSS). This study aimed to determine whether these high- and low-anxiety phenotypes correlate with changes in adrenal histomorphology and corticosteroid production.

METHODS: Rats were exposed to PSS for ten days. Thirty days later, the rats' anxiety index (AI) was assessed with an elevated plus-maze test. Based on differences in AI, the rats were segregated into low- (AI ≤ 0.8, n = 9) and high- (AI > 0.8, n = 10) anxiety phenotypes. Plasma corticosterone (CORT) concentrations were measured by ELISA. Adrenal CORT, desoxyCORT, and 11-dehydroCORT were measured by high-performance liquid chromatography. After staining with hematoxylin and eosin, adrenal histomorphometric changes were evaluated by measuring the thickness of the functional zones of the adrenal cortex.

RESULTS: Decreased plasma CORT concentrations, as well as decreased adrenal CORT, desoxyCORT and 11-dehydroCORT concentrations, were observed in high- but not in low-anxiety phenotypes. These decreases were associated with increases in AI. PSS led to a significant decrease in the thickness of the

CONCLUSION: Phenotype-associated changes in adrenal function and histomorphology were observed in a rat model of complex post-traumatic stress disorder.

Keywords: CPTSD; adrenal gland; behavior; glucocorticoids

References

  1. Ann N Y Acad Sci. 2004 Dec;1032:167-78 - PubMed
  2. Dev Cell. 2013 Oct 14;27(1):5-18 - PubMed
  3. Behav Brain Res. 2020 May 27;386:112591 - PubMed
  4. Hormones (Athens). 2017 Jul;16(3):251-265 - PubMed
  5. Ir J Psychol Med. 2019 Dec;36(4):305-315 - PubMed
  6. Eur Neuropsychopharmacol. 2014 Jan;24(1):142-7 - PubMed
  7. Endocrinology. 2018 Feb 1;159(2):579-596 - PubMed
  8. Dev Psychopathol. 2001 Summer;13(3):515-38 - PubMed
  9. J Neuroendocrinol. 2012 Jan;24(1):174-82 - PubMed
  10. Ann Endocrinol (Paris). 2018 Jun;79(3):98-106 - PubMed
  11. J Steroid Biochem Mol Biol. 2019 Jun;190:198-206 - PubMed
  12. Stress. 2020 Nov;23(6):662-666 - PubMed
  13. J Mol Endocrinol. 1996 Oct;17(2):121-30 - PubMed
  14. Endocr Res. 1998 Aug-Nov;24(3-4):643-7 - PubMed
  15. Endocrine. 1997 Dec;7(3):331-5 - PubMed
  16. Mol Psychiatry. 2019 Jan;24(1):2-9 - PubMed
  17. Psychoneuroendocrinology. 2005 Nov;30(10):1010-6 - PubMed
  18. Mol Metab. 2021 Jan;43:101112 - PubMed
  19. Nat Rev Endocrinol. 2021 Jul;17(7):421-434 - PubMed
  20. Transl Psychiatry. 2018 Oct 5;8(1):209 - PubMed
  21. Cell Stem Cell. 2019 Aug 1;25(2):290-296.e2 - PubMed
  22. J Appl Physiol (1985). 2018 Sep 1;125(3):931-937 - PubMed
  23. Eur Neuropsychopharmacol. 2011 Nov;21(11):796-809 - PubMed
  24. Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12997-13002 - PubMed
  25. Int J Mol Sci. 2020 Oct 09;21(20): - PubMed

Publication Types

Grant support