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Koistinen H, Künnapuu J, Jeltsch M. KLK3 in the Regulation of Angiogenesis-Tumorigenic or Not?. Int J Mol Sci. 2021;22(24)doi: 10.3390/ijms222413545.
Koistinen, H., Künnapuu, J., & Jeltsch, M. (2021). KLK3 in the Regulation of Angiogenesis-Tumorigenic or Not?. International journal of molecular sciences, 22(24), . https://doi.org/10.3390/ijms222413545
Koistinen, Hannu, et al. "KLK3 in the Regulation of Angiogenesis-Tumorigenic or Not?." International journal of molecular sciences vol. 22,24 (2021). doi: https://doi.org/10.3390/ijms222413545
Koistinen H, Künnapuu J, Jeltsch M. KLK3 in the Regulation of Angiogenesis-Tumorigenic or Not?. Int J Mol Sci. 2021 Dec 17;22(24). doi: 10.3390/ijms222413545. PMID: 34948344.
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Int J Mol Sci. 2021 Dec 17;22(24). doi: 10.3390/ijms222413545.

KLK3 in the Regulation of Angiogenesis-Tumorigenic or Not?.

International journal of molecular sciences

Hannu Koistinen, Jaana Künnapuu, Michael Jeltsch

Affiliations

  1. Department of Clinical Chemistry, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland.
  2. Drug Research Program, University of Helsinki, 00014 Helsinki, Finland.
  3. Individualized Drug Therapy Research Program, University of Helsinki, 00014 Helsinki, Finland.
  4. Wihuri Research Institute, 00290 Helsinki, Finland.

PMID: 34948344 DOI: 10.3390/ijms222413545

Abstract

In this focused review, we address the role of the kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen (PSA), in the regulation of angiogenesis. Early studies suggest that KLK3 is able to inhibit angiogenic processes, which is most likely dependent on its proteolytic activity. However, more recent evidence suggests that KLK3 may also have an opposite role, mediated by the ability of KLK3 to activate the (lymph)angiogenic vascular endothelial growth factors VEGF-C and VEGF-D, further discussed in the review.

Keywords: KLK3; PSA; VEGF-C; VEGF-D; angiogenesis; cancer; proteolysis

References

  1. Biol Chem. 2010 Apr;391(4):333-43 - PubMed
  2. Clin Cancer Res. 2000 Jan;6(1):160-5 - PubMed
  3. Arterioscler Thromb Vasc Biol. 2018 Jun;38(6):1346-1357 - PubMed
  4. Nat Rev Cancer. 2007 Apr;7(4):256-69 - PubMed
  5. Prostate. 2012 Aug 1;72(11):1233-8 - PubMed
  6. Prostate. 2017 Oct;77(14):1408-1415 - PubMed
  7. Blood. 2019 Nov 14;134(20):1764-1775 - PubMed
  8. Am J Pathol. 2012 Nov;181(5):1607-20 - PubMed
  9. Anal Biochem. 2008 May 15;376(2):229-34 - PubMed
  10. J Urol. 1999 May;161(5):1620-5 - PubMed
  11. Clin Chem. 2008 Jul;54(7):1248-9 - PubMed
  12. J Clin Invest. 2005 Feb;115(2):247-57 - PubMed
  13. Eur Urol. 2021 Dec;80(6):703-711 - PubMed
  14. Nat Med. 2001 Feb;7(2):192-8 - PubMed
  15. EMBO J. 1996 Jan 15;15(2):290-98 - PubMed
  16. Nat Med. 2001 Feb;7(2):186-91 - PubMed
  17. Prostate. 1988;12(1):39-46 - PubMed
  18. Lancet. 1994 Dec 10;344(8937):1594-8 - PubMed
  19. Med Oncol. 2012 Dec;29(4):2594-600 - PubMed
  20. Sci Rep. 2017 Sep 11;7(1):11225 - PubMed
  21. Nat Rev Drug Discov. 2005 May;Suppl:S8-9 - PubMed
  22. Methods Mol Biol. 2009;539:1-32 - PubMed
  23. Prostate. 2012 Oct 1;72(14):1588-94 - PubMed
  24. Curr Opin Urol. 2016 Sep;26(5):459-65 - PubMed
  25. Expert Opin Investig Drugs. 2021 Mar;30(3):193-200 - PubMed
  26. Sci Rep. 2019 Oct 30;9(1):15663 - PubMed
  27. J Clin Invest. 2016 Jun 1;126(6):2167-80 - PubMed
  28. Cancer Res. 2001 Mar 1;61(5):1786-90 - PubMed
  29. Endocr Relat Cancer. 2015 Jun;22(3):R107-23 - PubMed
  30. Am J Pathol. 2002 Sep;161(3):947-56 - PubMed
  31. Nucleic Acids Res. 2013 Sep;41(17):7997-8010 - PubMed
  32. Physiol Rev. 2011 Jul;91(3):1071-121 - PubMed
  33. J Exp Clin Cancer Res. 2010 Dec 28;29:171 - PubMed
  34. Clin Cancer Res. 2001 Jun;7(6):1533-8 - PubMed
  35. Front Cell Dev Biol. 2020 Nov 05;8:594903 - PubMed
  36. Oncotarget. 2019 Sep 10;10(52):5439-5453 - PubMed
  37. Prostate. 2001 Jun 15;48(1):1-6 - PubMed
  38. Angiogenesis. 2016 Jan;19(1):53-65 - PubMed
  39. FASEB J. 2011 Aug;25(8):2615-25 - PubMed
  40. PLoS One. 2014 Sep 19;9(9):e107819 - PubMed
  41. Sci Rep. 2017 Jul 7;7(1):4916 - PubMed
  42. Prostate. 2008 Aug 1;68(11):1143-51 - PubMed
  43. Prostate. 2015 Sep;75(12):1285-99 - PubMed
  44. Prostate. 2008 Jun 15;68(9):945-54 - PubMed
  45. Genes Dev. 2014 Nov 1;28(21):2331-47 - PubMed
  46. Front Pharmacol. 2021 Apr 20;12:667474 - PubMed
  47. Cancer Lett. 2004 Apr 15;207(1):79-87 - PubMed
  48. Clin Chem. 2007 Aug;53(8):1423-32 - PubMed
  49. Prostate. 2010 Nov 1;70(15):1692-700 - PubMed
  50. Prostate. 2010 May 15;70(7):788-96 - PubMed
  51. J Exp Med. 2010 Aug 30;207(9):1981-93 - PubMed
  52. Sci Transl Med. 2017 Sep 13;9(407): - PubMed
  53. Clin Genitourin Cancer. 2015 Aug;13(4):295-301 - PubMed
  54. J Clin Invest. 2004 Apr;113(7):1040-50 - PubMed
  55. Cancers (Basel). 2021 Jan 30;13(3): - PubMed
  56. Cancer Res. 2008 Sep 1;68(17):7110-9 - PubMed
  57. J Clin Invest. 1985 Nov;76(5):1899-903 - PubMed
  58. Blood. 2011 Feb 3;117(5):1507-15 - PubMed
  59. Int J Retina Vitreous. 2021 Oct 1;7(1):55 - PubMed
  60. Annu Rev Biomed Eng. 2021 Jul 13;23:141-167 - PubMed
  61. Oncol Lett. 2018 Jan;15(1):1072-1078 - PubMed
  62. J Am Chem Soc. 2021 Jun 16;143(23):8911-8924 - PubMed
  63. Am J Physiol Endocrinol Metab. 2011 Feb;300(2):E263-75 - PubMed
  64. J Biol Chem. 1989 Jan 25;264(3):1894-900 - PubMed
  65. Cell Mol Life Sci. 2013 Nov;70(22):4341-54 - PubMed
  66. Prostate. 2017 Feb;77(3):255-262 - PubMed
  67. Asian J Androl. 2006 Mar;8(2):169-75 - PubMed
  68. Cold Spring Harb Perspect Med. 2017 Sep 1;7(9): - PubMed
  69. BMC Cancer. 2009 Oct 12;9:362 - PubMed
  70. Am J Pathol. 2000 Mar;156(3):899-909 - PubMed
  71. Crit Rev Clin Lab Sci. 2016 Aug;53(4):277-91 - PubMed
  72. Prostate. 2011 Nov;71(15):1680-90 - PubMed
  73. J Biol Chem. 2008 Nov 7;283(45):30433-7 - PubMed
  74. Biology (Basel). 2021 Feb 23;10(2): - PubMed
  75. Circulation. 2014 May 13;129(19):1962-71 - PubMed
  76. Sci Rep. 2021 Apr 29;11(1):9264 - PubMed
  77. Cell Mol Life Sci. 2020 May;77(9):1745-1770 - PubMed
  78. Oncotarget. 2016 Jun 28;7(26):39421-39435 - PubMed
  79. Biochemistry. 1997 Apr 1;36(13):3811-9 - PubMed
  80. Biochim Biophys Acta. 2007 Sep;1776(1):22-31 - PubMed
  81. N Engl J Med. 1971 Nov 18;285(21):1182-6 - PubMed
  82. Nat Rev Cancer. 2007 Oct;7(10):800-8 - PubMed
  83. Prostate. 2007 Apr 1;67(5):485-99 - PubMed
  84. Oncogene. 2007 Mar 15;26(12):1731-8 - PubMed
  85. Prostate. 2005 Oct 1;65(2):110-6 - PubMed
  86. Cancer. 2011 Mar 15;117(6):1210-9 - PubMed
  87. Arthritis Rheum. 2011 Aug;63(8):2318-28 - PubMed
  88. Br J Cancer. 1999 Dec;81(8):1269-73 - PubMed
  89. J Cancer Res Clin Oncol. 2021 Dec;147(12):3477-3494 - PubMed
  90. Oncogene. 2005 Aug 18;24(35):5510-20 - PubMed
  91. Cancer Discov. 2014 Jan;4(1):31-41 - PubMed
  92. Target Oncol. 2014 Dec;9(4):359-66 - PubMed
  93. Prostate. 2011 Nov;71(15):1595-607 - PubMed
  94. Blood. 2011 Apr 28;117(17):4667-78 - PubMed
  95. EMBO J. 2001 Feb 15;20(4):672-82 - PubMed
  96. J Biol Chem. 1998 Apr 3;273(14):8413-8 - PubMed
  97. Scand J Clin Lab Invest. 2009;69(4):447-51 - PubMed
  98. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2210-2219 - PubMed
  99. Nat Rev Cancer. 2008 Apr;8(4):268-78 - PubMed
  100. Elife. 2019 May 17;8: - PubMed
  101. J Cell Biol. 1988 Oct;107(4):1589-98 - PubMed
  102. J Natl Cancer Inst. 1999 Oct 6;91(19):1635-40 - PubMed
  103. Prostate Int. 2020 Jun;8(2):62-69 - PubMed
  104. Prostate. 2013 May;73(6):563-72 - PubMed
  105. Endocr Rev. 2010 Aug;31(4):407-46 - PubMed
  106. Pharmacol Rev. 2016 Oct;68(4):1110-1142 - PubMed
  107. Prostate. 2003 Aug 1;56(3):212-9 - PubMed
  108. Molecules. 2014 May 23;19(5):6851-62 - PubMed
  109. Nucleic Acids Res. 2016 Jan 4;44(D1):D351-5 - PubMed
  110. Biol Chem. 2018 Sep 25;399(9):1023-1039 - PubMed
  111. Annu Rev Med. 2020 Jan 27;71:33-45 - PubMed
  112. Ann Oncol. 2018 Mar;29(3):529-532 - PubMed
  113. Biol Chem. 2010 Apr;391(4):299-310 - PubMed
  114. Cancer Metastasis Rev. 2019 Sep;38(3):333-346 - PubMed
  115. Molecules. 2019 Aug 07;24(16): - PubMed
  116. Expert Opin Ther Targets. 2016 Jul;20(7):801-18 - PubMed
  117. Cancer Cell. 2013 Jan 14;23(1):35-47 - PubMed
  118. Cold Spring Harb Perspect Med. 2018 Aug 1;8(8): - PubMed
  119. PLoS One. 2016 Nov 3;11(11):e0165725 - PubMed
  120. J Biol Chem. 2019 Feb 1;294(5):1643-1651 - PubMed
  121. Clin Chem. 2019 Jan;65(1):e1-e9 - PubMed

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