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Lan Z, Zhang Y, Sun Y, et al. Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS. Front Pharmacol. 2021;12:769021doi: 10.3389/fphar.2021.769021.
Lan, Z., Zhang, Y., Sun, Y., Wang, L., Huang, Y., Cao, H., Wang, S., & Meng, J. (2021). Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS. Frontiers in pharmacology, 12769021. https://doi.org/10.3389/fphar.2021.769021
Lan, Zhenwei, et al. "Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS." Frontiers in pharmacology vol. 12 (2021): 769021. doi: https://doi.org/10.3389/fphar.2021.769021
Lan Z, Zhang Y, Sun Y, Wang L, Huang Y, Cao H, Wang S, Meng J. Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS. Front Pharmacol. 2021 Dec 10;12:769021. doi: 10.3389/fphar.2021.769021. eCollection 2021. PMID: 34955839; PMCID: PMC8703108.
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Front Pharmacol. 2021 Dec 10;12:769021. doi: 10.3389/fphar.2021.769021. eCollection 2021.

Identifying of Anti-Thrombin Active Components From Curcumae Rhizoma by Affinity-Ultrafiltration Coupled With UPLC-Q-Exactive Orbitrap/MS.

Frontiers in pharmacology

Zhenwei Lan, Ying Zhang, Yue Sun, Lvhong Wang, Yuting Huang, Hui Cao, Shumei Wang, Jiang Meng

Affiliations

  1. School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica, State Administration of Traditional Chinese Medicine (TCM), Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province, Guangzhou, China.
  2. College of Pharmacy, Jinan University, Research Center for Traditional Chinese Medicine of Lingnan, Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization, Guangzhou, China.

PMID: 34955839 PMCID: PMC8703108 DOI: 10.3389/fphar.2021.769021

Abstract

Recent studies concerning products that originate from natural plants have sought to clarify active ingredients, which both explains the mechanisms of the function and aids in quality control during production. As a traditional functional plant, Curcumae Rhizoma (CR) has been proven to be effective in promoting blood circulation and removing blood stasis. However, the components that play a role in its huge compound library are still unclear. The present study aimed to develop a high-throughput screening method to identify thrombin inhibitors in CR and validate them by

Copyright © 2021 Lan, Zhang, Sun, Wang, Huang, Cao, Wang and Meng.

Keywords: affinity-ultrafiltration-MS; antithrombosis; curcumae rhizoma; diarylheptanoid; thrombin inhibitors; zebrafish

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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