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Jiang M, Xie X, Cao F, et al. Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease. Front Cardiovasc Med. 2021;8:789267doi: 10.3389/fcvm.2021.789267.
Jiang, M., Xie, X., Cao, F., & Wang, Y. (2021). Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease. Frontiers in cardiovascular medicine, 8789267. https://doi.org/10.3389/fcvm.2021.789267
Jiang, Min, et al. "Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease." Frontiers in cardiovascular medicine vol. 8 (2021): 789267. doi: https://doi.org/10.3389/fcvm.2021.789267
Jiang M, Xie X, Cao F, Wang Y. Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease. Front Cardiovasc Med. 2021 Dec 09;8:789267. doi: 10.3389/fcvm.2021.789267. eCollection 2021. PMID: 34957264; PMCID: PMC8695728.
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Front Cardiovasc Med. 2021 Dec 09;8:789267. doi: 10.3389/fcvm.2021.789267. eCollection 2021.

Mitochondrial Metabolism in Myocardial Remodeling and Mechanical Unloading: Implications for Ischemic Heart Disease.

Frontiers in cardiovascular medicine

Min Jiang, Xiaoye Xie, Feng Cao, Yabin Wang

Affiliations

  1. Department of Cardiology, National Clinical Research Center for Geriatric Disease, The Second Medical Center, Chinese People's Liberation Army General Hospital, Beijing, China.
  2. College of Pulmonary and Critical Care Medicine, Chinese People's Liberation Army General Hospital, Beijing, China.
  3. Medical School of Chinese People's Liberation Army, Chinese People's Liberation Army General Hospital, Beijing, China.
  4. Department of Cadre Ward, The 960 Hospital of Chinese People's Liberation Army, Jinan, China.

PMID: 34957264 PMCID: PMC8695728 DOI: 10.3389/fcvm.2021.789267

Abstract

Ischemic heart disease refers to myocardial degeneration, necrosis, and fibrosis caused by coronary artery disease. It can lead to severe left ventricular dysfunction (LVEF ≤ 35-40%) and is a major cause of heart failure (HF). In each contraction, myocardium is subjected to a variety of mechanical forces, such as stretch, afterload, and shear stress, and these mechanical stresses are clinically associated with myocardial remodeling and, eventually, cardiac outcomes. Mitochondria produce 90% of ATP in the heart and participate in metabolic pathways that regulate the balance of glucose and fatty acid oxidative phosphorylation. However, altered energetics and metabolic reprogramming are proved to aggravate HF development and progression by disturbing substrate utilization. This review briefly summarizes the current insights into the adaptations of cardiomyocytes to mechanical stimuli and underlying mechanisms in ischemic heart disease, with focusing on mitochondrial metabolism. We also discuss how mechanical circulatory support (MCS) alters myocardial energy metabolism and affects the detrimental metabolic adaptations of the dysfunctional myocardium.

Copyright © 2021 Jiang, Xie, Cao and Wang.

Keywords: heart failure; ischemic heart disease; left ventricular assist device; mechanical unloading; mitochondrial metabolism; veno-arterial ECMO

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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