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Lavergne J, Debin M, Blanchon T, et al. Perceived risk of opioid use disorder secondary to opioid analgesic medication use by the general population in France. Eur J Pain. 2021;doi: 10.1002/ejp.1901.
Lavergne, J., Debin, M., Blanchon, T., Colizza, V., Dassieu, L., Gimenez, L., Kengne-Kuetche, C., Lapeyre-Mestre, M., & Dupouy, J. (2021). Perceived risk of opioid use disorder secondary to opioid analgesic medication use by the general population in France. European journal of pain (London, England), . https://doi.org/10.1002/ejp.1901
Lavergne, Justine, et al. "Perceived risk of opioid use disorder secondary to opioid analgesic medication use by the general population in France." European journal of pain (London, England) vol. (2021). doi: https://doi.org/10.1002/ejp.1901
Lavergne J, Debin M, Blanchon T, Colizza V, Dassieu L, Gimenez L, Kengne-Kuetche C, Lapeyre-Mestre M, Dupouy J. Perceived risk of opioid use disorder secondary to opioid analgesic medication use by the general population in France. Eur J Pain. 2021 Dec 27; doi: 10.1002/ejp.1901. Epub 2021 Dec 27. PMID: 34958720.
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Eur J Pain. 2021 Dec 27; doi: 10.1002/ejp.1901. Epub 2021 Dec 27.

Perceived risk of opioid use disorder secondary to opioid analgesic medication use by the general population in France.

European journal of pain (London, England)

Justine Lavergne, Marion Debin, Thierry Blanchon, Vittoria Colizza, Lise Dassieu, Laetitia Gimenez, Charly Kengne-Kuetche, Maryse Lapeyre-Mestre, Julie Dupouy

Affiliations

  1. Département Universitaire de Médecine Générale, Université de Toulouse; Faculté de Médecine, 133 route de Narbonne, 31063, Toulouse, France.
  2. Sorbonne Université, Inserm, Institut Pierre Louis d'Epidémiologie et de Santé Publique, IPLESP, F-75012, Paris, France.
  3. Centre de Recherche du Centre Hospitalier de l'Université de Montréal, 850 rue Saint Denis, Montréal, QC, H2X0A9, Canada.
  4. CERPOP, Université de Toulouse, Inserm, UPS, Toulouse, France.
  5. CEIP-Addictovigilance, CIC 1436, Service de Pharmacologie Médicale et Clinique, Faculté de Médecine, 37 allées Jules Guesde, 31000, Toulouse, France.

PMID: 34958720 DOI: 10.1002/ejp.1901

Abstract

BACKGROUND: In Europe and France, the use of opioid analgesic drugs has become widespread as an option for pain management. However, their use can lead to nonmedical use and/or opioid use disorder (OUD). This work aimed to assess the perceived risk of OUD secondary to opioid analgesic drugs use by the general population.

METHODS: We conducted a cross-sectional observational study using the GrippeNet web-based cohort, comprising about 10,000 French volunteers from the general population, using a self-administered questionnaire. The main outcome was the perceived risk of OUD secondary to opioid analgesic drugs use, assessed by a 4-item scale and modeled using logistic regression (backward procedure).

RESULTS: Among 5,046 French respondents, after adjustment, 65% believed that the use of analgesic drugs could likely or very likely lead to OUD. Factors associated with perception of a higher risk were being over 50 and having heard about opioids in the media. Previous opioid use and a high level of education decreased the perception of the risk. Among those having used opioids in the past two years (N = 1770), 71.1% reported being not at all concerned by this risk. The majority of the sample perceived the risk of OUD but those having already used opioid analgesics drugs expressed no concern about this risk for themselves.

CONCLUSIONS: This finding highlight the need to reinforce warning on the package insert documents, therapeutic education and collaborative care between the prescribing general practitioners and pharmacists to increase awareness of opioid medications users on the risk of OUD.

This article is protected by copyright. All rights reserved.

Keywords: General population; General practitioner; Opioid analgesic; Opioid use disorder; Risk perception

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