Display options
Cite
Tuchin VV, Genina EA, Tuchina ES, et al. Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery. Adv Drug Deliv Rev. 2021;180:114037doi: 10.1016/j.addr.2021.114037.
Tuchin, V. V., Genina, E. A., Tuchina, E. S., Svetlakova, A. V., & Svenskaya, Y. I. (2022). Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery. Advanced drug delivery reviews, 180114037. https://doi.org/10.1016/j.addr.2021.114037
Tuchin, Valery V, et al. "Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery." Advanced drug delivery reviews vol. 180 (2022): 114037. doi: https://doi.org/10.1016/j.addr.2021.114037
Tuchin VV, Genina EA, Tuchina ES, Svetlakova AV, Svenskaya YI. Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery. Adv Drug Deliv Rev. 2022 Jan;180:114037. doi: 10.1016/j.addr.2021.114037. Epub 2021 Nov 06. PMID: 34752842.
Copy Download .nbib Format: NLM
Share it on

Adv Drug Deliv Rev. 2022 Jan;180:114037. doi: 10.1016/j.addr.2021.114037. Epub 2021 Nov 06.

Optical clearing of tissues: Issues of antimicrobial phototherapy and drug delivery.

Advanced drug delivery reviews

Valery V Tuchin, Elina A Genina, Elena S Tuchina, Anna V Svetlakova, Yulia I Svenskaya

Affiliations

  1. Science Medical Center, Saratov State University, Saratov 410012, Russian Federation; Institute of Physics, Saratov State University, Saratov 410012, Russian Federation; Laboratory of Laser Molecular Imaging and Machine Learning, National Research Tomsk State University, Tomsk 634050, Russian Federation; Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control of the Russian Academy of Sciences, Saratov 410028, Russian Federation; A.N. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Moscow 119071, Russian Federation. Electronic address: [email protected].
  2. Science Medical Center, Saratov State University, Saratov 410012, Russian Federation; Institute of Physics, Saratov State University, Saratov 410012, Russian Federation; Laboratory of Laser Molecular Imaging and Machine Learning, National Research Tomsk State University, Tomsk 634050, Russian Federation.
  3. Science Medical Center, Saratov State University, Saratov 410012, Russian Federation; Biological Department, Saratov State University, Saratov 410012, Russian Federation.
  4. Institute of Chemistry, Saint Petersburg State University, St. Petersburg 199034, Russian Federation.
  5. Science Medical Center, Saratov State University, Saratov 410012, Russian Federation.

PMID: 34752842 DOI: 10.1016/j.addr.2021.114037

Abstract

This review presents principles and novelties in the field of tissue optical clearing (TOC) technology, as well as application for optical monitoring of drug delivery and effective antimicrobial phototherapy. TOC is based on altering the optical properties of tissue through the introduction of immersion optical cleaning agents (OCA), which impregnate the tissue of interest. We also analyze various methods and kinetics of delivery of photodynamic agents, nanoantibiotics and their mixtures with OCAs into the tissue depth in the context of antimicrobial and antifungal phototherapy. In vitro and in vivo studies of antimicrobial phototherapies, such as photodynamic, photothermal plasmonic and photocatalytic, are summarized, and the prospects of a new TOC technology for effective killing of pathogens are discussed.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Acne; Adenoids; In vivo; Microbiota; Nanoantibiotics; Oral cavity; Pathogens; Photosensitizers; Skin; THz; Theranostics; Tonsils; UV

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

Publication Types