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Atanasov G, Rusew RI, Gelev VM, et al. New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3. Pharmaceuticals (Basel). 2021;14(12)doi: 10.3390/ph14121331.
Atanasov, G., Rusew, R. I., Gelev, V. M., Chanev, C. D., Nikolova, R., Shivachev, B. L., Petrov, O. I., & Apostolova, M. D. (2021). New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3. Pharmaceuticals (Basel, Switzerland), 14(12), . https://doi.org/10.3390/ph14121331
Atanasov, Gjorgji, et al. "New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3." Pharmaceuticals (Basel, Switzerland) vol. 14,12 (2021). doi: https://doi.org/10.3390/ph14121331
Atanasov G, Rusew RI, Gelev VM, Chanev CD, Nikolova R, Shivachev BL, Petrov OI, Apostolova MD. New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3. Pharmaceuticals (Basel). 2021 Dec 20;14(12). doi: 10.3390/ph14121331. PMID: 34959731.
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Pharmaceuticals (Basel). 2021 Dec 20;14(12). doi: 10.3390/ph14121331.

New Heterocyclic Combretastatin A-4 Analogs: Synthesis and Biological Activity of Styryl-2(3.

Pharmaceuticals (Basel, Switzerland)

Gjorgji Atanasov, Rusi I Rusew, Vladimir M Gelev, Christo D Chanev, Rosica Nikolova, Boris L Shivachev, Ognyan I Petrov, Margarita D Apostolova

Affiliations

  1. Roumen Tsanev Institute of Molecular Biology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria.
  2. Institute of Mineralogy and Crystallography, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 107, 1113 Sofia, Bulgaria.
  3. Department of Pharmaceutical and Applied Organic Chemistry, Faculty of Chemistry and Pharmacy, Sofia University St. Kliment Ohridski, 1 James Bourchier Blvd., 1164 Sofia, Bulgaria.

PMID: 34959731 DOI: 10.3390/ph14121331

Abstract

Here, we describe the synthesis, characterization, and biological activities of a series of 26 new styryl-2(3H)-benzothiazolone analogs of combretastatin-A4 (CA-4). The cytotoxic activities of these compounds were tested in several cell lines (EA.hy926, A549, BEAS-2B, MDA-MB-231, HT-29, MCF-7, and MCF-10A), and the relations between structure and cytotoxicity are discussed. From the series, compound (

Keywords: anticancer agents; benzothiazolones; combretastatin A-4; endothelial; stilbene; tubulin binding

Publication Types

Grant support