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Huang M, Watso JC, Belval LN, et al. Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia. Am J Physiol Regul Integr Comp Physiol. 2021;322(1):R55-R63doi: 10.1152/ajpregu.00217.2021.
Huang, M., Watso, J. C., Belval, L. N., Cimino, F. A., Fischer, M., Jarrard, C. P., Hendrix, J. M., Laborde, C. H., & Crandall, C. G. (2022). Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia. American journal of physiology. Regulatory, integrative and comparative physiology, 322(1), R55-R63. https://doi.org/10.1152/ajpregu.00217.2021
Huang, Mu, et al. "Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia." American journal of physiology. Regulatory, integrative and comparative physiology vol. 322,1 (2022): R55-R63. doi: https://doi.org/10.1152/ajpregu.00217.2021
Huang M, Watso JC, Belval LN, Cimino FA, Fischer M, Jarrard CP, Hendrix JM, Laborde CH, Crandall CG. Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia. Am J Physiol Regul Integr Comp Physiol. 2022 Jan 01;322(1):R55-R63. doi: 10.1152/ajpregu.00217.2021. Epub 2021 Dec 01. PMID: 34851734.
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Am J Physiol Regul Integr Comp Physiol. 2022 Jan 01;322(1):R55-R63. doi: 10.1152/ajpregu.00217.2021. Epub 2021 Dec 01.

Low-dose fentanyl does not alter muscle sympathetic nerve activity, blood pressure, or tolerance during progressive central hypovolemia.

American journal of physiology. Regulatory, integrative and comparative physiology

Mu Huang, Joseph C Watso, Luke N Belval, Frank A Cimino, Mads Fischer, Caitlin P Jarrard, Joseph M Hendrix, Carmen Hinojosa Laborde, Craig G Crandall

Affiliations

  1. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas.
  2. Department of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas.
  3. Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
  4. Department of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
  5. Department of Anesthesiology and Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas.
  6. United States Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, Texas.

PMID: 34851734 DOI: 10.1152/ajpregu.00217.2021

Abstract

Hemorrhage is a leading cause of battlefield and civilian trauma deaths. Several pain medications, including fentanyl, are recommended for use in the prehospital (i.e., field setting) for a hemorrhaging solider. However, it is unknown whether fentanyl impairs arterial blood pressure (BP) regulation, which would compromise hemorrhagic tolerance. Thus, the purpose of this study was to test the hypothesis that an analgesic dose of fentanyl impairs hemorrhagic tolerance in conscious humans. Twenty-eight volunteers (13 females) participated in this double-blinded, randomized, placebo-controlled trial. We conducted a presyncopal limited progressive lower body negative pressure test (LBNP; a validated model to simulate hemorrhage) following intravenous administration of fentanyl (75 µg) or placebo (saline). We quantified tolerance as a cumulative stress index (mmHg·min), which was compared between trials using a paired, two-tailed

Keywords: cerebral tissue oxygenation; opioids; respiration; sympathoexcitatory

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