Display options
Cite
Kaivola J, Nyman TA, Matikainen S. Inflammasomes and SARS-CoV-2 Infection. Viruses. 2021;13(12)doi: 10.3390/v13122513.
Kaivola, J., Nyman, T. A., & Matikainen, S. (2021). Inflammasomes and SARS-CoV-2 Infection. Viruses, 13(12), . https://doi.org/10.3390/v13122513
Kaivola, Juha, et al. "Inflammasomes and SARS-CoV-2 Infection." Viruses vol. 13,12 (2021). doi: https://doi.org/10.3390/v13122513
Kaivola J, Nyman TA, Matikainen S. Inflammasomes and SARS-CoV-2 Infection. Viruses. 2021 Dec 14;13(12). doi: 10.3390/v13122513. PMID: 34960782.
Copy Download .nbib Format: NLM
Share it on

Viruses. 2021 Dec 14;13(12). doi: 10.3390/v13122513.

Inflammasomes and SARS-CoV-2 Infection.

Viruses

Juha Kaivola, Tuula Anneli Nyman, Sampsa Matikainen

Affiliations

  1. Helsinki Rheumatic Disease and Inflammation Research Group, Translational Immunology Research Program, University of Helsinki, 00290 Helsinki, Finland.
  2. Department of Immunology, Institute of Clinical Medicine, University of Oslo and Rikshospitalet Oslo, 0372 Oslo, Norway.
  3. Finnish Medicines Agency (FIMEA), PL 55, FIMEA, 00034 Helsinki, Finland.

PMID: 34960782 DOI: 10.3390/v13122513

Abstract

SARS-CoV-2 is a new type of coronavirus that has caused worldwide pandemic. The disease induced by SARS-CoV-2 is called COVID-19. A majority of people with COVID-19 have relatively mild respiratory symptoms. However, a small percentage of COVID-19 patients develop a severe disease where multiple organs are affected. These severe forms of SARS-CoV-2 infections are associated with excessive production of pro-inflammatory cytokines, so called "cytokine storm". Inflammasomes, which are protein complexes of the innate immune system orchestrate development of local and systemic inflammation during virus infection. Recent data suggest involvement of inflammasomes in severe COVID-19. Activation of inflammasome exerts two major effects: it activates caspase-1-mediated processing and secretion of pro-inflammatory cytokines IL-1β and IL-18, and induces inflammatory cell death, pyroptosis, via protein called gasdermin D. Here, we provide comprehensive review of current understanding of the activation and possible functions of different inflammasome structures during SARS-CoV-2 infection and compare that to response caused by influenza A virus. We also discuss how novel SARS-CoV-2 mRNA vaccines activate innate immune response, which is a prerequisite for the activation of protective adaptive immune response.

Keywords: COVID-19; SARS-CoV-2; cytokines; inflammasomes; innate immunity

Publication Types

Grant support