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J Photochem Photobiol B. 2022 Jan;226:112370. doi: 10.1016/j.jphotobiol.2021.112370. Epub 2021 Nov 27.

Effects of free radicals from doxycycline hyclate and minocycline hydrochloride under blue light irradiation on the deactivation of Staphylococcus aureus, including a methicillin-resistant strain.

Journal of photochemistry and photobiology. B, Biology

Jeu-Ming P Yuann, Shwu-Yuan Lee, Sin He, Tak-Wah Wong, Meei-Ju Yang, Chien-Wei Cheng, Shiuh-Tsuen Huang, Ji-Yuan Liang

Affiliations

  1. Department of Biotechnology, Ming Chuan University, Gui Shan 333321, Taiwan.
  2. Department of Tourism and Leisure, Hsing Wu University, New Taipei City 244012, Taiwan.
  3. Department of Dermatology, National Cheng Kung University Hospital, Department of Biochemistry and Molecular Biology, College of Medicine, Center of Applied Nanomedicine, National Cheng Kung University, Tainan 70101, Taiwan.
  4. Tea Research and Extension Station, Yangmei 326011, Taiwan.
  5. Department of Science Education and Application, National Taichung University of Education, Taichung 40306, Taiwan; Department of Soil and Environmental Sciences, National Chung Hsing University, Taichung 40200, Taiwan. Electronic address: [email protected].
  6. Department of Biotechnology, Ming Chuan University, Gui Shan 333321, Taiwan. Electronic address: [email protected].

PMID: 34864528 DOI: 10.1016/j.jphotobiol.2021.112370

Abstract

Doxycycline hyclate (DCH) and minocycline hydrochloride (MH) are tetracycline antibiotics and broad-spectrum antimicrobial agents. The changes in DCH and MH under blue light (λ = 462 nm) irradiation in alkaline conditions (BLIA) were investigated. Deactivation caused by superoxide anion radical (O

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Blue light; Doxycycline; MRSA; Minocycline; Staphylococcus aureus

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