Display options
Share it on

J Pharm Biomed Anal. 2021 Nov 24;209:114487. doi: 10.1016/j.jpba.2021.114487. Epub 2021 Nov 24.

A review of green solvent extraction techniques and their use in antibiotic residue analysis.

Journal of pharmaceutical and biomedical analysis

Mohammad Mahdi Khataei, Shazalatun Binte Huda Epi, Rolf Lood, Peter Spégel, Yadollah Yamini, Charlotta Turner

Affiliations

  1. Lund University, Department of Chemistry, Centre for Analysis and Synthesis, P.O. Box 124, 22100 Lund, Sweden; Tarbiat Modares University, Department of Chemistry, P.O. Box 14115-175, Tehran, Iran.
  2. Lund University, Department of Chemistry, Centre for Analysis and Synthesis, P.O. Box 124, 22100 Lund, Sweden.
  3. Lund University, Department of Clinical Sciences, P.O. Box 124, 22100 Lund, Sweden.
  4. Tarbiat Modares University, Department of Chemistry, P.O. Box 14115-175, Tehran, Iran.
  5. Lund University, Department of Chemistry, Centre for Analysis and Synthesis, P.O. Box 124, 22100 Lund, Sweden. Electronic address: [email protected].

PMID: 34864593 DOI: 10.1016/j.jpba.2021.114487

Abstract

Antibiotic residues are being continuously recognized in the aquatic environment and in food. Though the concentration of antibiotic residues is typically low, adverse effects on the environment and human health have been observed. Hence, an efficient method to determine numerous antibiotic residues should be simple, inexpensive, selective, with high throughput and with low detection limits. Liquid-based extractions have been exceedingly used for clean-up and preconcentration of antibiotics prior to chromatographic analysis. In order to make methods more green and environmentally sustainable, conventional hazardous organic solvents can be replaced with green solvents. This review presents sampling strategies as well as comprehensive and up-to-date methods for chemical analysis of antibiotic residues in different sample matrices. Particularly, solvent-based sample preparation techniques using green solvents are discussed along with applications in antibiotic residue analysis.

Copyright © 2021 The Author(s). Published by Elsevier B.V. All rights reserved.

Keywords: Antibiotic residues; Deep eutectic solvents; Green solvents; Ionic liquids; Sample preparation; Subcritical water; Supercritical fluids

Conflict of interest statement

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this pa

Publication Types