Display options
Cite
Almeida CAF, Pereira-Junior AA, Rangel JG, et al. Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. Behav Brain Res. 2021;416:113546doi: 10.1016/j.bbr.2021.113546.
Almeida, C. A. F., Pereira-Junior, A. A., Rangel, J. G., Pereira, B. P., Costa, K. C. M., Bruno, V., Silveira, G. O., Ceron, C. S., Yonamine, M., Camarini, R., Garcia, R. C. T., Marcourakis, T., & Torres, L. H. (2022). Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. Behavioural brain research, 416113546. https://doi.org/10.1016/j.bbr.2021.113546
Almeida, Carolina Aparecida Faria, et al. "Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice." Behavioural brain research vol. 416 (2022): 113546. doi: https://doi.org/10.1016/j.bbr.2021.113546
Almeida CAF, Pereira-Junior AA, Rangel JG, Pereira BP, Costa KCM, Bruno V, Silveira GO, Ceron CS, Yonamine M, Camarini R, Garcia RCT, Marcourakis T, Torres LH. Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice. Behav Brain Res. 2022 Jan 07;416:113546. doi: 10.1016/j.bbr.2021.113546. Epub 2021 Aug 23. PMID: 34437939.
Copy Download .nbib Format: NLM
Share it on

Behav Brain Res. 2022 Jan 07;416:113546. doi: 10.1016/j.bbr.2021.113546. Epub 2021 Aug 23.

Ayahuasca, a psychedelic beverage, modulates neuroplasticity induced by ethanol in mice.

Behavioural brain research

Carolina Aparecida Faria Almeida, Antonio Alves Pereira-Junior, Jéssica Gonçalves Rangel, Bruna Pinheiro Pereira, Karla Cristinne Mancini Costa, Vitor Bruno, Gabriela Oliveira Silveira, Carla Speroni Ceron, Mauricio Yonamine, Rosana Camarini, Raphael Caio Tamborelli Garcia, Tania Marcourakis, Larissa Helena Torres

Affiliations

  1. Department of Food and Drugs, School of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro Da Silva, 700, 37130-001, Alfenas, MG, Brazil.
  2. Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 580, Bl. 13B, 05508-000, São Paulo, SP, Brazil.
  3. Department of Pharmacology, Institute of Biomedical Science, University of São Paulo, Av. Prof. Lineu Prestes, 1524, Prédio 1, 05508-900, São Paulo, SP, Brazil.
  4. Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Rua São Nicolau, 210, 1° Andar, 09913-030, Diadema, SP, Brazil.
  5. Department of Food and Drugs, School of Pharmaceutical Sciences, Federal University of Alfenas, Rua Gabriel Monteiro Da Silva, 700, 37130-001, Alfenas, MG, Brazil. Electronic address: [email protected].

PMID: 34437939 DOI: 10.1016/j.bbr.2021.113546

Abstract

Alcohol use disorder needs more effective treatments because relapse rates remain high. Psychedelics, such as ayahuasca, have been used to treat substance use disorders. Our study aimed to evaluate the effects of ayahuasca on ethanol-induced behavioral sensitization (EIBS). Swiss mice received 2.2 g/kg ethanol or saline IP injections every other day across nine days (D1, D3, D5, D7, and D9), and locomotor activity was evaluated 10 min after each injection. Then, animals were treated daily with ayahuasca (corresponding to 1.76 mg/kg of N,N-dimethyltryptamine, DMT) or water by oral gavage for eight consecutive days. On the seventh day, mice were evaluated in the elevated plus maze. Then, mice were challenged with a single dose of ethanol to measure their locomotor activity. Dopamine receptors, serotonin receptors, dynorphin, and prodynorphin levels were quantified in the striatum and hippocampus by blot analysis. Repeated ethanol administration resulted in EIBS. However, those animals treated with ayahuasca had an attenuated EIBS. Moreover, ayahuasca reduced the anxiogenic response to ethanol withdrawal and prevented the ethanol-induced changes on 5-HT1a receptor and prodynorphin levels in the hippocampus and reduced ethanol effects in the dynorphin/prodynorphin ratio levels in the striatum. These results suggest a potential application of ayahuasca to modulate the neuroplastic changes induced by ethanol.

Copyright © 2021 Elsevier B.V. All rights reserved.

Keywords: Ayahuasca; Behavioral sensitization; Ethanol; N,N-dimethyltryptamine; Withdrawal; β-carboline

Publication Types