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Stuart PE, Tsoi LC, Nair RP, et al. Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide. HGG Adv. 2021;3(1)doi: 10.1016/j.xhgg.2021.100069.
Stuart, P. E., Tsoi, L. C., Nair, R. P., Ghosh, M., Kabra, M., Shaiq, P. A., Raja, G. K., Qamar, R., Thelma, B. K., Patrick, M. T., Parihar, A., Singh, S., Khandpur, S., Kumar, U., Wittig, M., Degenhardt, F., Tejasvi, T., Voorhees, J. J., Weidinger, S., Franke, A., Abecasis, G. R., Sharma, V. K., & Elder, J. T. (2022). Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide. HGG advances, 3(1), . https://doi.org/10.1016/j.xhgg.2021.100069
Stuart, Philip E, et al. "Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide." HGG advances vol. 3,1 (2022). doi: https://doi.org/10.1016/j.xhgg.2021.100069
Stuart PE, Tsoi LC, Nair RP, Ghosh M, Kabra M, Shaiq PA, Raja GK, Qamar R, Thelma BK, Patrick MT, Parihar A, Singh S, Khandpur S, Kumar U, Wittig M, Degenhardt F, Tejasvi T, Voorhees JJ, Weidinger S, Franke A, Abecasis GR, Sharma VK, Elder JT. Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide. HGG Adv. 2022 Jan 13;3(1). doi: 10.1016/j.xhgg.2021.100069. Epub 2021 Nov 06. PMID: 34927100; PMCID: PMC8682265.
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HGG Adv. 2022 Jan 13;3(1). doi: 10.1016/j.xhgg.2021.100069. Epub 2021 Nov 06.

Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine-mapping in the MHC and genomewide.

HGG advances

Philip E Stuart, Lam C Tsoi, Rajan P Nair, Manju Ghosh, Madhulika Kabra, Pakeeza A Shaiq, Ghazala K Raja, Raheel Qamar, B K Thelma, Matthew T Patrick, Anita Parihar, Sonam Singh, Sujay Khandpur, Uma Kumar, Michael Wittig, Frauke Degenhardt, Trilokraj Tejasvi, John J Voorhees, Stephan Weidinger, Andre Franke, Goncalo R Abecasis, Vinod K Sharma, James T Elder

Affiliations

  1. Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI, USA.
  2. These authors contributed equally to this study.
  3. Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  4. Department of Computational Medicine & Bioinformatics, University of Michigan, Ann Arbor MI, USA.
  5. Department of Pediatrics Genetics, All India Institute of Medical Sciences, New Delhi, India.
  6. Department of Biochemistry, PMASAA University, Rawalpindi, Pakistan.
  7. COMSATS Institute of Information Technology, Islamabad, Pakistan.
  8. Department of Genetics, University of Delhi South Campus, 110021 New Delhi, India.
  9. Department of Dermatology, All India Institute of Medical Sciences, New Delhi, India.
  10. Department of Rheumatology, All India Institute of Medical Sciences, New Delhi, India.
  11. Institute of Clinical Molecular Biology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.
  12. Ann Arbor Veterans Affairs Hospital, Ann Arbor, MI, USA.
  13. Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel 24105, Germany.

PMID: 34927100 PMCID: PMC8682265 DOI: 10.1016/j.xhgg.2021.100069

Abstract

Because transethnic analysis may facilitate prioritization of causal genetic variants, we performed a genomewide association study (GWAS) of psoriasis in South Asians (SAS), consisting of 2,590 cases and 1,720 controls. Comparison with our existing European-origin (EUR) GWAS showed that effect sizes of known psoriasis signals were highly correlated in SAS and EUR (Spearman ρ = 0.78;

Keywords: genome-wide association study; human leukocyte antigens; imputation; major histocompatibility complex

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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