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Dayanand D, Irudhayanathan I, Kundu D, et al. Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention. Int J Infect Dis. 2021;doi: 10.1016/j.ijid.2021.12.356.
Dayanand, D., Irudhayanathan, I., Kundu, D., Manesh, A., Abraham, V., Abhilash, K. P., Chacko, B., Moorthy, M., Samuel, P., Peerawaranun, P., Mukaka, M., Joseph, J., Sivaprakasam, M., & Varghese, G. M. (2021). Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, . https://doi.org/10.1016/j.ijid.2021.12.356
Dayanand, Divya, et al. "Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention." International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases vol. (2021). doi: https://doi.org/10.1016/j.ijid.2021.12.356
Dayanand D, Irudhayanathan I, Kundu D, Manesh A, Abraham V, Abhilash KP, Chacko B, Moorthy M, Samuel P, Peerawaranun P, Mukaka M, Joseph J, Sivaprakasam M, Varghese GM. Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention. Int J Infect Dis. 2021 Dec 28; doi: 10.1016/j.ijid.2021.12.356. Epub 2021 Dec 28. PMID: 34971822.
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Int J Infect Dis. 2021 Dec 28; doi: 10.1016/j.ijid.2021.12.356. Epub 2021 Dec 28.

Community seroprevalence and risk factors for SARS CoV-2 infection in different subpopulations in Vellore, India and its implications for future prevention.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Divya Dayanand, Indhuja Irudhayanathan, Debasree Kundu, Abi Manesh, Vinod Abraham, Kundavaram Pp Abhilash, Binila Chacko, Mahesh Moorthy, Prasanna Samuel, Pimnara Peerawaranun, Mavuto Mukaka, Jayaraj Joseph, Mohanasankar Sivaprakasam, George M Varghese

Affiliations

  1. Department of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India.
  2. Department of Community Health, Christian Medical College, Vellore, Tamil Nadu, India.
  3. Department of Emergency Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
  4. Department of Critical Care Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
  5. Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, India.
  6. Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.
  7. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  8. Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, University of Oxford, UK.
  9. Department of Electrical Engineering, Indian Institute of TechnologyMadras, Tamil Nadu, India; Healthcare Technology Innovation Centre (HTIC), Indian Institute of Technology Madras, Tamil Nadu, India.
  10. Department of Infectious Diseases, Christian Medical College, Vellore, Tamil Nadu, India. Electronic address: [email protected].

PMID: 34971822 DOI: 10.1016/j.ijid.2021.12.356

Abstract

OBJECTIVES: To inform public health policy decisions through assessment of IgG antibody seroprevalence in the population and the risk factors for SARS-CoV-2 infection.

METHODS: We estimated the seroprevalence of IgG antibodies among different subpopulations at the end of the first and second waves of the pandemic. We also assessed various risk factors associated with the seropositivity including socio demography, IgG antibodies against endemic human coronavirus and vaccination status.

RESULTS: Of the 2433 consented participants, the overall estimated seroprevalence at the end of first and second waves were 28.5% (95% CI:22.3%-33.7%) and 71.5% (95% CI:62.8%-80.5%), respectively. The accrual of IgG positivity was heterogeneous, with highest seroprevalence among the urban slum population(75.1%). Vaccine uptake was varied among the subpopulations, with low rates (<10%) among the rural and urban slums. The majority of seropositive individuals (75%) were asymptomatic. Residence in urban slums (OR 2.02; 95% CI:1.57-2.6; p<0.001), middle socioeconomic status (OR 1.77; 95% CI:1.17-2.67; p=0.007), presence of diabetes (OR 1.721; 95% CI:1.148-2.581; p=0.009), and hypertension (OR 1.75; 95% CI:1.16-2.64; p=0.008) were associated with seropositivity on multivariable analyses.

CONCLUSION: Although considerable population immunity has been reached with more than two-thirds seropositivity, improved vaccination strategies among unreached subpopulations and high-risk individuals are suggested for better preparedness in future.

Copyright © 2021. Published by Elsevier Ltd.

Keywords: COVID; India; SARS CoV 2; Seroprevalence

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