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Gorbunova AS, Kopeina GS, Zhivotovsky B. A Balance Between Autophagy and Other Cell Death Modalities in Cancer. Methods Mol Biol. 2022;2445:3-24doi: 10.1007/978-1-0716-2071-7_1.
Gorbunova, A. S., Kopeina, G. S., & Zhivotovsky, B. (2022). A Balance Between Autophagy and Other Cell Death Modalities in Cancer. Methods in molecular biology (Clifton, N.J.), 24453-24. https://doi.org/10.1007/978-1-0716-2071-7_1
Gorbunova, Anna S, et al. "A Balance Between Autophagy and Other Cell Death Modalities in Cancer." Methods in molecular biology (Clifton, N.J.) vol. 2445 (2022): 3-24. doi: https://doi.org/10.1007/978-1-0716-2071-7_1
Gorbunova AS, Kopeina GS, Zhivotovsky B. A Balance Between Autophagy and Other Cell Death Modalities in Cancer. Methods Mol Biol. 2022;2445:3-24. doi: 10.1007/978-1-0716-2071-7_1. PMID: 34972982.
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Methods Mol Biol. 2022;2445:3-24. doi: 10.1007/978-1-0716-2071-7_1.

A Balance Between Autophagy and Other Cell Death Modalities in Cancer.

Methods in molecular biology (Clifton, N.J.)

Anna S Gorbunova, Gelina S Kopeina, Boris Zhivotovsky

Affiliations

  1. Faculty of Basic Medicine, Lomonosov Moscow State University, Moscow, Russia.
  2. Faculty of Basic Medicine, Lomonosov Moscow State University, Moscow, Russia. [email protected].
  3. Karolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden. [email protected].

PMID: 34972982 DOI: 10.1007/978-1-0716-2071-7_1

Abstract

Autophagy is an intracellular self-digestive process involved in catabolic degradation of damaged proteins, and organelles, and the elimination of cellular pathogens. Initially, autophagy was considered as a prosurvival mechanism, but the following insights shed light on its prodeath function. Nowadays, autophagy is established as a crucial player in the development of various diseases through interaction with other molecular pathways within a cell. Additionally, disturbance in autophagy is one of the main pathological alterations that lead to resistance of cancer cells to treatment. These autophagy-related pathologies gave rise to the development of new therapeutic drugs. Here, we summarize the current knowledge on the autophagic role in disease pathogenesis, particularly in cancer, and the interplay between autophagy and other cell death modalities in order to combat cancer.

© 2022. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.

Keywords: Apoptosis; Autophagy; Autophagy-dependent cell death; Cancer; Necroptosis

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