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Bui S, Mejia I, Díaz B, et al. Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis. Front Cell Dev Biol. 2021;9:806482doi: 10.3389/fcell.2021.806482.
Bui, S., Mejia, I., Díaz, B., & Wang, Y. (2021). Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis. Frontiers in cell and developmental biology, 9806482. https://doi.org/10.3389/fcell.2021.806482
Bui, Sarah, et al. "Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis." Frontiers in cell and developmental biology vol. 9 (2021): 806482. doi: https://doi.org/10.3389/fcell.2021.806482
Bui S, Mejia I, Díaz B, Wang Y. Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis. Front Cell Dev Biol. 2021 Dec 10;9:806482. doi: 10.3389/fcell.2021.806482. eCollection 2021. PMID: 34957124; PMCID: PMC8703019.
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Front Cell Dev Biol. 2021 Dec 10;9:806482. doi: 10.3389/fcell.2021.806482. eCollection 2021.

Adaptation of the Golgi Apparatus in Cancer Cell Invasion and Metastasis.

Frontiers in cell and developmental biology

Sarah Bui, Isabel Mejia, Begoña Díaz, Yanzhuang Wang

Affiliations

  1. Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, United States.
  2. Department of Internal Medicine, Division of Medical Hematology and Oncology, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, United States.
  3. David Geffen School of Medicine and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, CA, United States.
  4. Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI, United States.

PMID: 34957124 PMCID: PMC8703019 DOI: 10.3389/fcell.2021.806482

Abstract

The Golgi apparatus plays a central role in normal cell physiology by promoting cell survival, facilitating proliferation, and enabling cell-cell communication and migration. These roles are partially mediated by well-known Golgi functions, including post-translational modifications, lipid biosynthesis, intracellular trafficking, and protein secretion. In addition, accumulating evidence indicates that the Golgi plays a critical role in sensing and integrating external and internal cues to promote cellular homeostasis. Indeed, the unique structure of the mammalian Golgi can be fine-tuned to adapt different Golgi functions to specific cellular needs. This is particularly relevant in the context of cancer, where unrestrained proliferation and aberrant survival and migration increase the demands in Golgi functions, as well as the need for Golgi-dependent sensing and adaptation to intrinsic and extrinsic stressors. Here, we review and discuss current understanding of how the structure and function of the Golgi apparatus is influenced by oncogenic transformation, and how this adaptation may facilitate cancer cell invasion and metastasis.

Copyright © 2021 Bui, Mejia, Díaz and Wang.

Keywords: Golgi; cancer; dissemination; metastasis; oncogenic transformation; proliferation; signaling; tumorigenesis

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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