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Di Guida R, Casillo A, Stellavato A, et al. Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation. Carbohydr Polym. 2021;278:118908doi: 10.1016/j.carbpol.2021.118908.
Di Guida, R., Casillo, A., Stellavato, A., Kawai, S., Ogawa, T., Di Meo, C., Kawamoto, J., Kurihara, T., Schiraldi, C., & Corsaro, M. M. (2022). Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation. Carbohydrate polymers, 278118908. https://doi.org/10.1016/j.carbpol.2021.118908
Di Guida, Rossella, et al. "Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation." Carbohydrate polymers vol. 278 (2022): 118908. doi: https://doi.org/10.1016/j.carbpol.2021.118908
Di Guida R, Casillo A, Stellavato A, Kawai S, Ogawa T, Di Meo C, Kawamoto J, Kurihara T, Schiraldi C, Corsaro MM. Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation. Carbohydr Polym. 2022 Feb 15;278:118908. doi: 10.1016/j.carbpol.2021.118908. Epub 2021 Nov 19. PMID: 34973729.
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Carbohydr Polym. 2022 Feb 15;278:118908. doi: 10.1016/j.carbpol.2021.118908. Epub 2021 Nov 19.

Capsular polysaccharide from a fish-gut bacterium induces/promotes apoptosis of colon cancer cells in vitro through Caspases' pathway activation.

Carbohydrate polymers

Rossella Di Guida, Angela Casillo, Antonietta Stellavato, Soichiro Kawai, Takuya Ogawa, Celeste Di Meo, Jun Kawamoto, Tatsuo Kurihara, Chiara Schiraldi, Maria Michela Corsaro

Affiliations

  1. Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. Electronic address: [email protected].
  2. Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. Electronic address: [email protected].
  3. Department of Experimental Medicine, Section of Biotechnology Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", via L. De Crecchio n 7, 80138 Naples, Italy. Electronic address: [email protected].
  4. Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. Electronic address: [email protected].
  5. Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. Electronic address: [email protected].
  6. Department of Experimental Medicine, Section of Biotechnology Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", via L. De Crecchio n 7, 80138 Naples, Italy. Electronic address: [email protected].
  7. Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. Electronic address: [email protected].
  8. Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. Electronic address: [email protected].
  9. Department of Experimental Medicine, Section of Biotechnology Medical Histology and Molecular Biology, University of Campania "Luigi Vanvitelli", via L. De Crecchio n 7, 80138 Naples, Italy. Electronic address: [email protected].
  10. Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Naples, Italy. Electronic address: [email protected].

PMID: 34973729 DOI: 10.1016/j.carbpol.2021.118908

Abstract

Among the widespread malignancies colorectal cancer is the most lethal. Treatments of this malignant tumor include surgery for lesions and metastases, radiotherapy, immunotherapy, and chemotherapy. Nevertheless, novel therapies to reduce morbidity and mortality are demanding. Natural products, such as polysaccharides, can be a valuable alternative to sometimes very toxic chemotherapeutical agents, also because they are biocompatible and biodegradable biomaterials. Microbial polysaccharides have been demonstrated to fulfill this requirement. In this paper, the results about the structure and the activity of a capsular polysaccharide isolated from the psychrotroph Pseudoalteromonas nigrifaciens Sq02-Rif

Copyright © 2021 Elsevier Ltd. All rights reserved.

Keywords: Anti-cancer; Bioinformatic analysis; Capsular polysaccharide; Cold-adapted bacterium; Molecular weight; Structural determination

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