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Aryan M, Jariwala R, Alkurdi B, et al. Prevalence of metabolic syndrome in cirrhotics with gastric antral vascular ectasia. Diabetes Metab Syndr. 2021;16(1):102377doi: 10.1016/j.dsx.2021.102377.
Aryan, M., Jariwala, R., Alkurdi, B., Peter, S., & Shoreibah, M. (2021). Prevalence of metabolic syndrome in cirrhotics with gastric antral vascular ectasia. Diabetes & metabolic syndrome, 16(1), 102377. https://doi.org/10.1016/j.dsx.2021.102377
Aryan, Mahmoud, et al. "Prevalence of metabolic syndrome in cirrhotics with gastric antral vascular ectasia." Diabetes & metabolic syndrome vol. 16,1 (2021): 102377. doi: https://doi.org/10.1016/j.dsx.2021.102377
Aryan M, Jariwala R, Alkurdi B, Peter S, Shoreibah M. Prevalence of metabolic syndrome in cirrhotics with gastric antral vascular ectasia. Diabetes Metab Syndr. 2021 Dec 25;16(1):102377. doi: 10.1016/j.dsx.2021.102377. Epub 2021 Dec 25. PMID: 34974327.
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Diabetes Metab Syndr. 2021 Dec 25;16(1):102377. doi: 10.1016/j.dsx.2021.102377. Epub 2021 Dec 25.

Prevalence of metabolic syndrome in cirrhotics with gastric antral vascular ectasia.

Diabetes & metabolic syndrome

Mahmoud Aryan, Ravi Jariwala, Basem Alkurdi, Shajan Peter, Mohamed Shoreibah

Affiliations

  1. Tinsley Harrison Internal Medicine Residency Program, Department of Medicine, University of Alabama at Birmingham, 1720 2nd Avenue South, BDB 327, Birmingham, AL, 35294, United States. Electronic address: [email protected].
  2. Tinsley Harrison Internal Medicine Residency Program, Department of Medicine, University of Alabama at Birmingham, 1720 2nd Avenue South, BDB 327, Birmingham, AL, 35294, United States; Department of Gastroenterology and Hepatology, Ochsner Medical Center, 1514 Jefferson Hwy. New Orleans, LA, 70121, United States.
  3. Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama at Birmingham, 1808 7th Avenue South, BDB 391, Birmingham, AL, 35294, United States.

PMID: 34974327 DOI: 10.1016/j.dsx.2021.102377

Abstract

BACKGROUND AND AIMS: Gastric antral vascular ectasia (GAVE) is characterized by angliodysplastic lesions that can cause upper gastrointestinal bleeding (UGIB). The mechanism behind GAVE and its association with other diseases remains unknown. We investigated the association of metabolic syndrome in cirrhotic GAVE patients when compared to esophageal variceal hemorrhage (EVH) patients.

METHODS: We performed a retrospective review of 941 consecutive esophagogastroduodenoscopies (EGDs) for UGIB at a medical center between 2017 and 2019. The GAVE group consisted of EGD or biopsy diagnosed cirrhotic GAVE patients, and the EVH group consisted of EVH patients with active bleeding or stigmata of recent hemorrhage on EGD. Baseline variables including co-morbidities and cirrhotic etiology were recorded. Continuous variables were compared using Wilcoxon test and categorical variables were compared using Chi-square or Fisher's exact test. Multiple logistic regression analysis evaluated the association between GAVE and covariates.

RESULTS: The final cohort had 96 GAVE and 104 EVH patients. Mean BMI was significantly higher in the GAVE cohort (32.6 vs 27.9, p < 0.0001) in addition to diabetes, hypertension, and hyperlipidemia (53.1% vs 37.5%; 76% vs 47.1%; 38.5% vs 14.4%; respectively, all p < 0.05). Non-alcoholic steatohepatitis (NASH) cirrhosis was more prevalent in GAVE than EVH patients (50% vs 24%, p = 0.0001). Multiple logistics regression revealed female sex, increased BMI, hypertension, and hyperlipidemia all having significantly higher risk of GAVE (all p < 0.05).

CONCLUSION: Our data indicates that when compared to cirrhotics patients with EVH, cirrhotics with GAVE have increased risk of metabolic syndrome. This may play a role in the underlying pathophysiology of GAVE.

Copyright © 2021 Diabetes India. Published by Elsevier Ltd. All rights reserved.

Keywords: Cirrhosis; GAVE; Gastric antral vascular ectasia; Hypertension; Metabolic syndrome

Conflict of interest statement

Declaration of competing interest No authors have any conflicts of interest to declare.

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